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Related Concept Videos

Exercise and Muscle Performance01:27

Exercise and Muscle Performance

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Exercise induces a range of adaptations in muscle tissue, depending on the type and duration of activity. Such physical training can be broadly categorized into two types: endurance exercises and resistance exercises.
Endurance exercises
Endurance exercises involve running, swimming, or cycling, which require repetitive movements with low force output. When a person engages in endurance exercise, a few noticeable changes occur in their skeletal muscles. For instance, the number of capillaries...
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Targeted Cancer Therapies02:57

Targeted Cancer Therapies

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
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mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

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The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
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Treatment Resistant Cancers02:56

Treatment Resistant Cancers

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Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
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Clinical Trials: Overview01:11

Clinical Trials: Overview

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Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
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Cancer Therapies02:49

Cancer Therapies

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Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
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Related Experiment Video

Updated: Dec 21, 2025

The Evoked Potential Operant Conditioning System EPOCS: A Research Tool and an Emerging Therapy for Chronic Neuromuscular Disorders
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The Evoked Potential Operant Conditioning System EPOCS: A Research Tool and an Emerging Therapy for Chronic Neuromuscular Disorders

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Exercise-oncology research: past, present, and future.

Lee W Jones1, Catherine M Alfano

  • 1Duke Cancer Institute, Durham, NC 27710, USA. lee.w.jones@duke.edu

Acta Oncologica (Stockholm, Sweden)
|December 19, 2012
PubMed
Summary

Exercise therapy is safe and effective for cancer patients, improving quality of life and potentially prognosis. Future research will further define its role in cancer care.

Area of Science:

  • Exercise oncology research
  • Cancer survivorship
  • Clinical trial analysis

Background:

  • Exercise oncology has advanced significantly over the last two decades.
  • Reflecting on past research is crucial for identifying future research priorities.
  • Understanding exercise therapy's role post-cancer diagnosis is key for clinical practice.

Purpose of the Study:

  • To systematically review existing literature and ongoing studies on exercise therapy in cancer patients.
  • To identify knowledge gaps in exercise oncology research across the cancer survivorship continuum.
  • To inform future research directions and enhance clinical care for cancer survivors.

Main Methods:

  • Utilized the Physical Exercise Across the Cancer Experience (PEACE) framework for systematic overview.

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Ex Vivo Treatment Response of Primary Tumors and/or Associated Metastases for Preclinical and Clinical Development of Therapeutics
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Ex Vivo Treatment Response of Primary Tumors and/or Associated Metastases for Preclinical and Clinical Development of Therapeutics

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Conducting Maximal and Submaximal Endurance Exercise Testing to Measure Physiological and Biological Responses to Acute Exercise in Humans
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  • Conducted a systematic review of exercise trials in adult cancer patients from Clinical Trials.gov and ICTRN.
  • Analyzed published and ongoing studies covering pretreatment, during treatment, and post-treatment phases.

    • Main Results:

    • Exercise therapy is a safe and well-tolerated adjunct treatment, mitigating side effects.
    • Observational data suggests higher exercise levels correlate with improved prognosis in solid tumor patients.
    • Identified 82 ongoing clinical studies, predominantly in breast cancer patients, focusing on quality of life, fatigue, and physical functioning.

    Conclusions:

    • Substantial knowledge gains have been made in exercise therapy for cancer survivors over 25 years.
    • The current evidence base supports launching next-generation research in exercise oncology.
    • Future research aims to improve both the quantity and quality of life for individuals diagnosed with cancer.