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Updated: May 15, 2026
08:02
In Vivo Augmentation of Gut-Homing Regulatory T Cell Induction
Published on: January 22, 2020
Expanding roles for GILT in immunity.
Laura Ciaccia West1, Peter Cresswell
1Department of Immunobiology and Howard Hughes Medical Institute, Yale University School of Medicine, 300, Cedar Street, New Haven, CT 06520-8011, USA.
Current Opinion in Immunology
|December 19, 2012
Summary
Gamma-interferon-inducible lysosomal thiol reductase (GILT) aids antigen processing for immune responses. GILT also plays unexpected roles in host defense and cellular health, expanding its known functions.
Area of Science:
- Immunology
- Molecular Biology
- Biochemistry
Background:
- Gamma-interferon-inducible lysosomal thiol reductase (GILT) is a thioredoxin-related oxidoreductase crucial for antigen processing.
- GILT facilitates antigen presentation by reducing disulfide bonds in endocytosed proteins, aiding their degradation.
Purpose of the Study:
- To explore the expanded functions of GILT beyond traditional antigen processing.
- To investigate GILT's role in immune response modulation and host-pathogen interactions.
Main Methods:
- Analysis of GILT's impact on peptide repertoire generation.
- Investigation of GILT's involvement in Listeria monocytogenes infection.
- Assessment of GILT's role in maintaining cellular glutathione (GSH) levels.
- Detection of secreted GILT from activated macrophages.
Main Results:
- GILT influences the peptide repertoire, altering immune responses and central tolerance.
- GILT acts as a host factor for Listeria monocytogenes infection.
- GILT contributes to the maintenance of cellular glutathione (GSH) levels.
- Enzymatically active GILT is secreted by activated macrophages, suggesting extracellular functions.
Conclusions:
- GILT's functions extend significantly beyond its established role in antigen processing.
- GILT is implicated in host defense, cellular homeostasis, and potentially extracellular immune modulation.
- Further research into GILT's diverse roles is warranted to fully understand its impact on immunity and disease.
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