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Updated: May 15, 2026

Drug-Induced Sleep Endoscopy (DISE) with Target Controlled Infusion (TCI) and Bispectral Analysis in Obstructive Sleep Apnea
Published on: December 6, 2016
[Non-CPAP therapies in obstructive sleep apnoea: an overview]
S Keymel1, M Kelm, W J Randerath
1Heinrich-Heine Universität Düsseldorf, Medizinische Fakultät, Klinik für Kardiologie, Pneumologie und Angiologie, Universitätsklinikum Düsseldorf.
Obstructive sleep apnoea syndrome (OSAS) treatment requires personalized care. While continuous positive airway pressure (CPAP) is standard, alternative therapies like mandibular devices and multilevel surgery show promise for specific cases.
Area of Science:
- Sleep Medicine
- Respiratory Medicine
- Otolaryngology
Context:
- Obstructive sleep apnoea syndrome (OSAS) necessitates individualized, interdisciplinary treatment strategies.
- Continuous positive airway pressure (CPAP) is the primary therapy for OSAS.
- Non-CPAP therapies are considered for CPAP failure or intolerance, though evidence varies.
Purpose:
- To review current and emerging treatment options for obstructive sleep apnoea syndrome (OSAS).
- To evaluate the efficacy and evidence level of various non-CPAP interventions.
- To discuss the future of surgical approaches for OSAS management.
Summary:
- CPAP is the first-line treatment for OSAS, but non-CPAP options exist.
- Mandibular advancement devices are effective for mild to moderate OSAS.
- Innovative treatments like neurostimulation and multilevel surgery show future potential, with limited evidence for most non-CPAP therapies.
Impact:
- Highlights the need for personalized OSAS treatment plans.
- Identifies effective non-CPAP alternatives for specific patient groups.
- Suggests future directions in surgical management for improved OSAS outcomes.
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