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Related Experiment Video

Updated: May 15, 2026

Digital PCR for Quantifying Circulating MicroRNAs in Acute Myocardial Infarction and Cardiovascular Disease
04:41

Digital PCR for Quantifying Circulating MicroRNAs in Acute Myocardial Infarction and Cardiovascular Disease

Published on: July 3, 2018

Circulating miRNA as novel markers for diastolic dysfunction.

Nandini Nair1, Sandeep Kumar, Enrique Gongora

  • 1Scott & White Memorial Hospital/TAMHSC College of Medicine, Temple, TX 76508, USA. nanair@swmail.sw.org

Molecular and Cellular Biochemistry
|December 19, 2012
PubMed
Summary
This summary is machine-generated.

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New circulating microRNAs (miRNAs) show distinct expression patterns in patients with diastolic dysfunction. These miRNAs may serve as novel biomarkers for diagnosing diastolic dysfunction, even with preserved systolic function.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Cardiology

Background:

  • MicroRNAs (miRNAs) are small noncoding RNAs regulating gene expression.
  • Serum miRNA signatures are increasingly linked to various disease conditions.
  • Plasma miRNA detection shows diagnostic potential for cardiovascular disorders.

Purpose of the Study:

  • To identify candidate miRNAs for diagnosing isolated diastolic dysfunction (DD) with preserved systolic function.
  • To analyze miRNA profiling in patients with DD, dilated cardiomyopathy (DCM), and congestive heart failure (DCM-CHF).

Main Methods:

  • Examined miRNA profiling in isolated diastolic dysfunction.
  • Tested miRNA presence in stable DD, compensated DCM, and decompensated DCM-CHF patients.
  • Identified specific circulating miRNAs with distinct expression patterns.

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Tissue-specific miRNA Expression Profiling in Mouse Heart Sections Using In Situ Hybridization
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Tissue-specific miRNA Expression Profiling in Mouse Heart Sections Using In Situ Hybridization

Published on: September 15, 2018

Related Experiment Videos

Last Updated: May 15, 2026

Digital PCR for Quantifying Circulating MicroRNAs in Acute Myocardial Infarction and Cardiovascular Disease
04:41

Digital PCR for Quantifying Circulating MicroRNAs in Acute Myocardial Infarction and Cardiovascular Disease

Published on: July 3, 2018

Tissue-specific miRNA Expression Profiling in Mouse Heart Sections Using In Situ Hybridization
08:22

Tissue-specific miRNA Expression Profiling in Mouse Heart Sections Using In Situ Hybridization

Published on: September 15, 2018

Main Results:

  • Identified novel circulating miRNAs (miR-454, miR-500, miR-1246, miR-142-3p) in diastolic dysfunction.
  • miR-454 and miR-500 were downregulated; miR-1246 was upregulated in diastolic dysfunction.
  • miR-142-3p and miR-124-5p showed differential expression in DCM and DCM-CHF groups.

Conclusions:

  • Circulating miRNAs exhibit distinct expression patterns in diastolic dysfunction.
  • The identified miRNAs may serve as novel biomarkers for diastolic dysfunction.
  • Systolic function status does not appear to influence these miRNA trends.