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Updated: May 15, 2026
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Translational Orthotopic Models of Glioblastoma Multiforme
Published on: February 17, 2023
Pediatric glioblastoma multiforme: A single-institution experience
Mansour Ansari1, Hamid Nasrolahi, Amir-Abbas Kani
1Department of Radiation Oncology, Student Research Committee, Namazi Hospital, Shiraz University of Medical Sciences, Shiraz, Iran.
Summary
Pediatric Glioblastoma Multiforme (GBM) is rare, with a median survival of 16 months in this study. Factors like age and treatment influenced survival outcomes in young patients.
Area of Science:
- Neuro-oncology
- Pediatric Oncology
Background:
- Glioblastoma Multiforme (GBM) is a common adult brain tumor with poor prognosis.
- GBM is rare in pediatric patients, necessitating specific research.
- This study focuses on the clinical experience with pediatric GBM.
Purpose of the Study:
- To analyze the clinical characteristics and outcomes of pediatric GBM patients.
- To identify prognostic factors for survival in children and adolescents with GBM.
Main Methods:
- Retrospective evaluation of 23 pediatric patients (≤20 years) diagnosed with GBM between 1990-2008.
- Analysis of patient demographics, treatment modalities (radiotherapy, chemotherapy), and survival data.
Main Results:
- The mean age of patients was 15.2 years, with a male predominance (14/23).
- Mean survival was 16.0 months; two patients survived over 5 years.
- Age, radiation dose, and performance status were significant prognostic factors for survival.
Conclusions:
- Pediatric GBM is uncommon, and outcomes remain unfavorable.
- Identifying prognostic factors is crucial for managing pediatric GBM.
