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Radioprotective property of an aqueous extract from valeriana wallichii
Omika Katoch1, Shikha Kaushik, Mysore Sadashiv Yogendra Kumar
1Institute of Nuclear Medicine and Allied Sciences, Defence Research and Development Organisation, Lucknow Road, Timarpur, Delhi, India.
Objectives:
Preparations of herbal drugs have drawn considerable interest in scientific community in recent years for the treatment of several stress related health problems including radiation-injury.
Materials And Methods:
An aqueous extract from Valeriana wallichii containing hesperidin as one of its major constituent was evaluated for its ability to protect against radiation-injury in model systems like plasmid deoxyribonucleic acid (DNA) and cultured human fibroblast cells.
Results:
The extract was found to significantly counter radiation-induced free radicals at 4 h after 5 Gy irradiation, reduced prolonged oxidative stress led increase in mitochondrial mass, enhanced reproductive viability of cultured cells and protected against radiation-induced DNA damage in solution.
Discussion:
Further studies are required to validate the radioprotective ability of the extract and to develop a safer radioprotective agent.