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B Cell Activation and Differentiation01:24

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The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
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Updated: May 15, 2026

Flow Cytometry-Based Quantification and Analysis of Myocardial B-Cells
12:46

Flow Cytometry-Based Quantification and Analysis of Myocardial B-Cells

Published on: August 17, 2022

B cell subsets in atherosclerosis.

Heather M Perry1, Timothy P Bender, Coleen A McNamara

  • 1Department of Pathology, University of Virginia Charlottesville, VA, USA ; Cardiovascular Research Center, University of Virginia Health System Charlottesville, VA, USA.

Frontiers in Immunology
|December 19, 2012
PubMed
Summary
This summary is machine-generated.

B cells, crucial immune cells, have varied effects on atherosclerosis, the artery disease causing heart attacks and strokes. Specific B cell subsets, like B-1a cells, may protect against atherosclerosis, while others might promote it.

Keywords:
B cellIgMatherosclerosiscytokineslipids

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Last Updated: May 15, 2026

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Published on: May 6, 2014

Area of Science:

  • Immunology
  • Cardiovascular Disease
  • Inflammation

Background:

  • Atherosclerosis is a chronic inflammatory artery disease linked to heart attacks and strokes.
  • Immune cells, particularly lymphocytes, significantly influence atherosclerotic lesion development.
  • Emerging research highlights the complex and subset-dependent role of B cells in atherosclerosis.

Purpose of the Study:

  • To review current understanding of B cell subsets in atherosclerosis.
  • To explore how different B cell populations impact disease progression.
  • To discuss the translational potential of these findings for human cardiovascular disease.

Main Methods:

  • Literature review of key studies on B cells and atherosclerosis.
  • Analysis of evidence for subset-specific B cell functions.
  • Discussion of factors influencing B cell roles, such as niche and disease stage.

Main Results:

  • B cell influence on atherosclerosis is subset-dependent.
  • B-1a B cells may offer protection via natural IgM antibodies.
  • Conventional B-2 B cells might promote atherosclerosis, potentially involving CD4 T cells.

Conclusions:

  • Distinct B cell subsets exert differential effects on atherosclerosis.
  • Understanding these roles is critical for developing new therapeutic strategies.
  • Translating B cell subset research into clinical applications for atherosclerosis is a key future direction.