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Related Experiment Video

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Flow Cytometry-Based Quantification and Analysis of Myocardial B-Cells
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B Cell Subsets and Atherosclerosis: Updates and Emerging Concepts.

Sophieke Lems1, Megan Grace Mazzei2, Amanda C Foks1

  • 1Division of BioTherapeutics, Leiden Academic Centre for Drug Research, Leiden University, Leiden, the Netherlands.

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PubMed
Summary
This summary is machine-generated.

B cells play a complex role in atherosclerotic cardiovascular disease (ASCVD). This review details how specific B cell subsets, like protective IgM+ B cells and age-associated B cells (ABCs), influence ASCVD progression and therapeutic strategies.

Keywords:
B cellsatherosclerosisimmunoglobulinsimmunotherapyoxidation‐specific epitopes

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Area of Science:

  • Immunology
  • Cardiovascular Medicine
  • Vascular Biology

Background:

  • Atherosclerotic cardiovascular disease (ASCVD) involves complex immune system interactions.
  • B cells have a significant, yet varied, role in the development of atherosclerosis.

Purpose of the Study:

  • To review the diverse roles of B cell subsets in ASCVD.
  • To explore mechanisms by which B cells influence atherosclerosis.
  • To discuss potential immunomodulatory therapies targeting B cells.

Main Methods:

  • Review of preclinical models and human studies on B cells in ASCVD.
  • Analysis of B cell subset functions, including antigen presentation and cytokine secretion.
  • Integration of findings on humoral immunity and antibody effector functions.

Main Results:

  • Distinct B cell subsets, such as protective IgM+ B cells and age-associated B cells (ABCs), have opposing effects on atherosclerosis.
  • Mechanisms include antigen presentation, immune checkpoint communication, and cytokine/chemokine secretion.
  • Humoral immunity in ASCVD depends on antibody properties and targets, not just antibody class.

Conclusions:

  • Understanding B cell heterogeneity is crucial for ASCVD research.
  • Targeted immunotherapies can be developed by modulating specific B cell functions.
  • Future therapies may enhance atheroprotective B cell activity while reducing atherogenic responses.