Circulating endothelial cells (CECs) and E-selectin: Predictors of preeclampsia

Area of Science:

• Obstetrics and Gynecology
• Maternal-Fetal Medicine
• Cardiovascular Research

Background:

• Endothelial dysfunction is a hallmark of preeclampsia.
• Circulating endothelial cells (CECs) and E-selectin are recognized markers of endothelial dysfunction.

Purpose of the Study:

• To determine if CECs and E-selectin can serve as predictive biomarkers for preeclampsia.
• To investigate the utility of measuring CECs and E-selectin in early third-trimester pregnancies for preeclampsia prediction.

Main Methods:

• Prospective study of 523 pregnant women (28-30 weeks gestation) undergoing a rollover test.
• CECs measured via immunomagnetic isolation in women with a positive rollover test.
• Follow-up until delivery to diagnose preeclampsia; comparison of CECs and E-selectin levels between preeclamptic and normotensive groups.

Main Results:

• Of 47 women with a positive rollover test, 22 developed preeclampsia.
• Significantly higher mean CEC numbers (24.7 cells/mL vs. 13 cells/mL) and E-selectin levels in preeclamptic women.
• CEC cut-off of 6.5 cells/mL showed 78.9% sensitivity and 69.1% specificity for preeclampsia.

Conclusions:

• Elevated CECs and E-selectin levels in early third-trimester pregnancies with a positive rollover test predict preeclampsia development.
• These biomarkers may be useful for early prediction of preeclampsia.
• Further research with larger cohorts is recommended to validate these findings.