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Updated: May 15, 2026

Direct Mouse Trauma/Burn Model of Heterotopic Ossification
Published on: August 6, 2015
Intra-abdominal heterotopic ossification of the peritoneum following traumatic splenic rupture
Orestis Ioannidis1, Argiro Sekouli, George Paraskevas
1First Surgical Department, George Papanikolaou General Regional Hospital, Thessaloniki, Greece.
Abstract:
Intra-abdominal heterotopic ossification is extremely rare with only approximately 30 cases having been reported. While most reported cases have involved the mesentery, ossification of the peritoneum is even rarer. The pathogenesis remains undetermined but is generally considered a reactive process in response to various stimuli. Histologically, it is composed of a peripheral area with bone formation and a central area of reactive hypercellular fibrous tissue. We report a rare case of intra-abdominal heterotopic ossification of the parietal peritoneum following traumatic splenic rupture.
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