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Trimeric hemibastadin congener from the marine sponge Ianthella basta
Hendrik Niemann1, Wenhan Lin, Werner E G Müller
1Institute of Pharmaceutical Biology and Biotechnology, Heinrich-Heine University, Universitätsstrasse 1, 40225 Düsseldorf, Germany.
Abstract:
The first naturally occurring trimeric hemibastadin congener, sesquibastadin 1 (1), and the previously reported bastadins 3, 6, 7, 11, and 16 (2-6) were isolated from the marine sponge Ianthella basta, collected in Indonesia. The structure of 1 was elucidated on the basis of 1D and 2D NMR measurements and by HRMS. Among all the isolated compounds, the linear sesquibastadin 1 (1) and bastadin 3 (2) showed the strongest inhibition rates for at least 22 protein kinases (IC(50) = 0.1-6.5 μM), while the macrocyclic bastadins (3-6) demonstrated a strong cytotoxic potential against the murine lymphoma cell line L5178Y (IC(50) = 1.5-5.3 μM).
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