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Updated: May 15, 2026

Platelet-Derived Extracellular Vesicle Functionalization of Ti Implants
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Published on: August 5, 2021

Plasma-based biofunctionalization of vascular implants.

Steven G Wise1, Anna Waterhouse, Alexey Kondyurin

  • 1School of Molecular Bioscience, University of Sydney, NSW 2006, Australia.

Nanomedicine (London, England)
|December 20, 2012
PubMed
Summary
This summary is machine-generated.

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Plasma treatments enhance cardiovascular device materials for better biointegration. These surface modifications improve vascular compatibility for polymers and metals, reducing foreign body responses.

Area of Science:

  • Biomaterials Science
  • Surface Chemistry
  • Cardiovascular Engineering

Background:

  • Cardiovascular devices utilize polymeric and metallic materials, necessitating surface modifications to improve biointegration and mitigate foreign body responses.
  • Host interactions at the implant surface trigger foreign body responses, highlighting the need for advanced surface engineering.
  • Current materials face challenges in achieving optimal vascular compatibility and long-term performance in vivo.

Purpose of the Study:

  • To review evolving plasma treatment technologies for biofunctionalizing implantable cardiovascular materials.
  • To explore how plasma modifications impact surface chemistry, wettability, and biomolecule binding on diverse substrates.
  • To assess the influence of these modifications on vascular compatibility, including endothelialization and blood interactions.

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Autologous Endothelial Progenitor Cell-Seeding Technology and Biocompatibility Testing For Cardiovascular Devices in Large Animal Model
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Autologous Endothelial Progenitor Cell-Seeding Technology and Biocompatibility Testing For Cardiovascular Devices in Large Animal Model

Published on: September 9, 2011

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Last Updated: May 15, 2026

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Published on: August 5, 2021

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Wet Chemistry and Peptide Immobilization on Polytetrafluoroethylene for Improved Cell-adhesion

Published on: August 15, 2016

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11:49

Autologous Endothelial Progenitor Cell-Seeding Technology and Biocompatibility Testing For Cardiovascular Devices in Large Animal Model

Published on: September 9, 2011

Main Methods:

  • Review of plasma-based surface modification techniques applied to polymers and metals.
  • Analysis of methods for modulating surface properties like chemistry, wettability, and roughness.
  • Examination of strategies for covalent biomolecule attachment and coating deposition on metallic substrates.

Main Results:

  • Plasma treatments effectively modify surface chemistry, wettability, and roughness of polymers like Dacron and ePTFE.
  • Plasma modification of metallic substrates presents challenges, requiring robust interface adhesion for coating deposition.
  • Surface modifications influence endothelialization and blood contact, crucial for vascular compatibility.

Conclusions:

  • Plasma technology offers versatile solutions for biofunctionalizing cardiovascular implant materials.
  • Optimized surface modifications are key to enhancing biointegration and vascular compatibility of both polymeric and metallic devices.
  • Continued advancements in plasma treatment are crucial for developing next-generation implantable cardiovascular devices.