Related Experiment Video

Updated: May 15, 2026

Assessing Cellular Stress and Inflammation in Discrete Oxytocin-secreting Brain Nuclei in the Neonatal Rat Before and After First Colostrum Feeding
09:12

Assessing Cellular Stress and Inflammation in Discrete Oxytocin-secreting Brain Nuclei in the Neonatal Rat Before and After First Colostrum Feeding

Published on: November 14, 2018

Brain natriuretic Peptide production and secretion in inflammation

Tsuneo Ogawa1, Adolfo J de Bold

  • 1Cardiovascular Endocrinology Laboratory, University of Ottawa Heart Institute, 40 Ruskin Street, Ottawa, ON, Canada K1Y 4W7.

Journal of Transplantation
|December 20, 2012
PubMed

Insights

Inflammation selectively increases brain natriuretic peptide (BNP) in cardiac disorders, unlike atrial natriuretic factor (ANF). This finding offers insights into cardiac inflammation and BNP regulation.

Area of Science:

  • Cardiology
  • Molecular Biology
  • Immunology

Background:

  • Cardiac polypeptide hormones atrial natriuretic factor (ANF) and brain natriuretic peptide (BNP) are upregulated in cardiac disorders.
  • Hemodynamic and neuroendocrine changes are key in cardiac disease progression.
  • Acute cardiac allograft rejection elevates plasma BNP but not ANF.

Purpose of the Study:

  • To investigate the selective regulation of BNP gene expression by inflammatory substances.
  • To understand the differential response of ANF and BNP to inflammation in cardiac conditions.

Main Methods:

  • Utilized cardiomyocyte cultures to study the effects of cytokines (TNFα and IL-1β) on ANF and BNP expression.
  • Observed in vivo changes in plasma BNP levels during acute cardiac allograft rejection, sepsis, and acute myocarditis.

Main Results:

  • Cytokines TNFα and IL-1β selectively stimulated cardiac BNP at transcriptional and translational levels in vitro.
  • ANF expression was unaffected by these cytokines in cardiomyocyte cultures.
  • Elevated plasma BNP levels were observed in vivo during acute cardiac allograft rejection, sepsis, and acute myocarditis, correlating with inflammation.

Conclusions:

  • Inflammation, mediated by cytokines, selectively upregulates BNP gene expression and secretion in cardiomyocytes.
  • This selective BNP response to inflammation is a significant factor in specific cardiac conditions like allograft rejection, sepsis, and myocarditis.
  • BNP may serve as a more specific biomarker for inflammation-driven cardiac events compared to ANF.

More Related Videos

Isolation of Atrial Myocytes from Adult Mice08:34

Isolation of Atrial Myocytes from Adult Mice

Published on: July 25, 2019

An Optimized Evans Blue Protocol to Assess Vascular Leak in the Mouse06:39

An Optimized Evans Blue Protocol to Assess Vascular Leak in the Mouse

Published on: September 12, 2018

Related Concept Videos

Hormonal Regulation of Blood Pressure01:17

Hormonal Regulation of Blood Pressure

Endocrinal or hormonal intervention in the cardiovascular system is predominantly exerted by the catecholamines - epinephrine and norepinephrine, as well as a slew of hormones that interact with renal function to modulate blood volume.
Epinephrine and Norepinephrine
The adrenal medulla releases epinephrine and norepinephrine, catecholamines that enhance and extend the sympathetic or "fight or flight" physiological response. These hormones escalate heart rate and the force of contraction while...
Hormonal Regulation01:33

Hormonal Regulation

The renin-aldosterone system is an endocrine system which guides the renal absorption of water and electrolytes, thus managing blood pressure and osmoregulation. Activation of the system begins in the kidneys with a small cluster of cells adjacent to the afferent and efferent blood vessels of the renal corpuscle. As the nephrons are filtering blood, juxtaglomerular cells monitor blood pressure. If they detect a decrease in pressure, they release the hormone renin into the bloodstream.
Hormonal Regulation01:40

Hormonal Regulation

Hormones regulate a significant portion of digestion through activation of the neuroendocrine system. The neuroendocrine system of digestion contains many different hormones all with multiple functions that are both, directly and indirectly, involved in digestion.
Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
Acute Inflammation III: Local and Systemic Effects01:25

Acute Inflammation III: Local and Systemic Effects

Acute inflammation produces a coordinated set of local and systemic changes that limit injury, eliminate pathogens, and initiate repair. These responses arise within minutes of infection, trauma, or chemical insult and are driven by vascular alterations and leukocyte-derived mediators. When the stimulus resolves, the reaction typically abates within days.Local EffectsAt the site of injury, arteriolar vasodilation increases blood flow, resulting in redness and warmth. Simultaneously, increased...
Neural Regulation of Blood Pressure01:18

Neural Regulation of Blood Pressure

The neural regulation of blood pressure involves intricate interactions between the autonomic nervous system (ANS) and cardiovascular system, ensuring adequate perfusion of tissues. This regulation primarily occurs through baroreceptor and chemoreceptor reflexes, involving both short-term and long-term mechanisms.
Baroreceptor Reflex
Baroreceptors, located in the carotid sinuses and aortic arch, detect changes in blood pressure. When blood pressure rises, these stretch-sensitive receptors...