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[Correlation of coronary heart disease with multiple genes, gene polymorphisms and multiple risk factors in old

Yu-Fa Sun1, Jian Cao, Xiao-Li Li

  • 1First Department of Geriatric Cardiology of South Building, Chinese PLA General Hospital, Beijing 100853, China.

Zhongguo Ying Yong Sheng Li Xue Za Zhi = Zhongguo Yingyong Shenglixue Zazhi = Chinese Journal of Applied Physiology
|December 21, 2012
PubMed

Insights

Aging, hypertension, and lower antithrombin III (ATIII) levels are key risk factors for coronary heart disease (CHD) in elderly Chinese Han patients. Genetic variations in platelet glycoprotein, angiotensin-converting enzyme, and ATIII also contribute to CHD susceptibility.

Area of Science:

  • Cardiovascular Medicine
  • Genetics
  • Geriatrics

Background:

  • Coronary heart disease (CHD) poses a significant health challenge, particularly among aging populations.
  • Identifying risk factors and genetic predispositions is crucial for effective prevention and management of CHD in the elderly Chinese Han demographic.

Purpose of the Study:

  • To investigate the clinical risk factors associated with CHD in old Chinese Han patients.
  • To explore the genetic susceptibility to CHD by examining specific single nucleotide polymorphisms (SNPs).

Main Methods:

  • A case-control study involving 246 CHD patients and 185 controls.
  • Logistic regression analysis was used to assess correlations between CHD and 15 risk factors.
  • Genotyping of 11 SNPs across 10 genes was performed using high-throughput systems.

Main Results:

  • Aging, hypertension, and lower antithrombin III (ATIII) levels were identified as significant risk factors for CHD (P < 0.05).
  • Specific SNPs, including GP1BA rs2243093, ACE rs4332, and ATIII rs2227589, showed associations with CHD.
  • Certain genotypes and alleles of these SNPs demonstrated significant odds ratios and confidence intervals for CHD risk.

Conclusions:

  • Aging, hypertension, and diminished ATIII levels are primary risk factors for CHD in the studied population.
  • The renin-angiotensin system, platelet function, and anti-coagulation pathways are implicated in the pathogenesis of CHD in elderly Chinese Han individuals.
Abstract

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