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Updated: May 15, 2026

Isolation and Th17 Differentiation of Naïve CD4 T Lymphocytes
Published on: September 26, 2013
T-helper 17 cells: the driving force of psoriasis and psoriatic arthritis
In Seol Yoo1, Jeung Hoon Lee, Seung Tak Song
1Department of Internal Medicine, Chungnam National University School of Medicine, Daejeon, Korea.
Aim:
There is growing evidence that two recently recognized, unique subsets of CD4(+) T-cells, T-helper 17 cells (Th17) and CD4(+) CD25(+) regulatory T-cells (Treg), may play important roles in the pathogenesis of psoriasis. This study sought to investigate the relationship between Th17 cells and psoriasis or psoriatic arthritis (PsA).
Methods:
Peripheral blood CD4(+) T-cells were isolated from 47 patients with psoriasis and 47 controls, and were cultured under various stimulatory conditions. The Th17 cells and regulatory Treg cells were detected by flow cytometry. Plasma interleukin (IL)-17 was measured by enzyme-linked immunosorbent assay.
Results:
The proportion of Th17 and Treg cells from peripheral blood mononuclear cells showed no difference between patients with psoriasis and controls. However, psoriasis and PsA patients demonstrated a higher proportion of induced Th17 cells, which was correlated with psoriasis area severity index score. The level of plasma IL-17A in psoriasis was higher than that in controls.
Conclusion:
Th17 cells may play important roles in the pathogenesis of psoriasis and psoriatic arthritis.
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