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Percutaneous Contrast Echocardiography-guided Intramyocardial Injection and Cell Delivery in a Large Preclinical Model
Published on: January 21, 2018
CDC Grand Rounds: the million hearts initiative
Insights
Cardiovascular disease, the leading cause of death, impacts millions annually. Managing preventable risk factors like high blood pressure and cholesterol can significantly reduce heart attack and stroke mortality.
Area of Science:
- Public Health
- Epidemiology
- Preventive Medicine
Background:
- Cardiovascular disease (CVD), encompassing heart disease and stroke, is the primary cause of mortality and morbidity in the U.S.
- Annually, approximately 2 million Americans experience a heart attack or stroke, leading to nearly 800,000 deaths.
- Survivors often face chronic illness, disability, and reduced quality of life, imposing a substantial economic burden.
Purpose of the Study:
- To highlight the significant public health impact of cardiovascular disease in the United States.
- To underscore the economic burden associated with cardiovascular disease expenditures and lost productivity.
- To emphasize the preventability of major cardiovascular disease risk factors and the potential for risk reduction.
Main Methods:
- Analysis of national statistics on cardiovascular disease incidence, mortality, and economic costs.
- Identification and review of primary modifiable risk factors for cardiovascular disease.
- Assessment of the impact of risk factor control on mortality rates.
Main Results:
- Cardiovascular disease is the leading cause of death and disability in the U.S., with 2 million affected and 800,000 deaths annually.
- The economic impact in 2010 was nearly $444 billion in healthcare costs and lost productivity, with costs projected to rise.
- Key risk factors including high blood pressure, high cholesterol, smoking, type 2 diabetes, inactivity, and obesity are largely preventable.
Conclusions:
- Effective management of modifiable risk factors through behavioral changes and treatment can substantially reduce cardiovascular disease mortality.
- Controlling primary risk factors could decrease the risk of death from heart attack and stroke by over 50%.
- Public health initiatives focusing on prevention and management of these risk factors are crucial for mitigating the impact of cardiovascular disease.
Abstract:
Cardiovascular disease, including heart disease and stroke, is the leading cause of death and disability in the United States. Every year, approximately 2 million persons in the United States have a heart attack or stroke and, as a result of these conditions, approximately 800,000 die from cardiovascular disease. For those persons who do survive a heart attack or stroke, many are faced with serious illness, disability, and decreased quality of life. The ongoing complications that result from cardiovascular disease greatly contribute to the economic burden on the health-care system and to society as a whole. In 2010, the cost in health-care expenditures and lost productivity in the United States from cardiovascular disease amounted to nearly $444 billion, and these costs are increasing every year. This is especially alarming because the primary risk factors for cardiovascular disease (i.e., high blood pressure, high cholesterol, smoking, type 2 diabetes, inactivity, and obesity) are largely preventable and have effective, low-cost treatments. If these risk factors were well-controlled through behavioral modification and/or treatment, the risk for death from heart attack and stroke could be reduced by more than half.
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