Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Indirect-Acting Cholinergic Agonists: Pharmacological Actions01:30

Indirect-Acting Cholinergic Agonists: Pharmacological Actions

Indirect-acting cholinergic agonists, also known as anticholinesterases, exert their pharmacological effects by enhancing cholinergic transmission in various body parts, including the neuromuscular junction, autonomic cholinergic synapses, and the brain.
At the neuromuscular junction, these agents work by inhibiting the breakdown of acetylcholine, allowing it to remain bound to the receptor and bind to nearby receptors. This process leads to repetitive firing of the endplate, causing muscle...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Bridging Research, Policy, and Practice: Advancing Evidence-Informed Approaches for Dementia Care and Prevention: an expert review by the Health Policy Professional Interest Area from ISTAART.

Alzheimer's & dementia. Behavior & socioeconomics of aging·2026
Same author

Authorship and citation trends in dementia research: A path to equitable career development for scientists.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same author

The Population Neuroscience-Dementia Syndemics Framework to better understand global sex and gender-based risk in low- and middle-income countries.

Nature aging·2026
Same author

Foundations of prosopagnosia: The three classic Austro-German reports.

Cortex; a journal devoted to the study of the nervous system and behavior·2025
Same author

Scanning faces: a deep learning approach to studying eye movements in prosopagnosia.

Frontiers in neurology·2025
Same author

Not Seeing and Seeing Things: Dementia, Visual Function, and Psychiatric Symptoms.

Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society·2025
Same journal

Changes in synergy formation and modulation during cyclic finger force production tasks in female adults with dystonic cerebral palsy.

Experimental brain research·2026
Same journal

Molecular links between reelin downregulation, topoisomerase IIβ alterations, and proteins involved in Alzheimer pathology in human SH-SY5Y neuroblastoma cell line.

Experimental brain research·2026
Same journal

Motor cortex excitability during spine shape-judgment in adolescent idiopathic scoliosis: a TMS motor evoked potential study.

Experimental brain research·2026
Same journal

Trajectory dynamics and endpoint accuracy in targeted ballistic contractions.

Experimental brain research·2026
Same journal

Exploring Sevoflurane promotes hippocampal neuron mitophagy in elderly postoperative cognitive dysfunction by HSP90AA1 based on network pharmacology.

Experimental brain research·2026
Same journal

Loading modulates monosynaptic transmission from spindle primary afferents to motoneurons in humans.

Experimental brain research·2026
See all related articles

Related Experiment Video

Updated: May 15, 2026

Investigating the Deployment of Visual Attention Before Accurate and Averaging Saccades via Eye Tracking and Assessment of Visual Sensitivity
06:46

Investigating the Deployment of Visual Attention Before Accurate and Averaging Saccades via Eye Tracking and Assessment of Visual Sensitivity

Published on: March 18, 2019

The global effect for antisaccades.

Jayalakshmi Viswanathan1, Jason J S Barton

  • 1Human Vision and Eye Movement Laboratory, Department of Medicine (Neurology), University of British Columbia, Third floor, VGH Eye Care Center, 2550 Willow Street, Vancouver, BC, V5Z 3N9, Canada. jaya.neuro@gmail.com

Experimental Brain Research
|December 21, 2012
PubMed
Summary
This summary is machine-generated.

The global effect in eye movements, specifically antisaccades, is larger than in prosaccades, suggesting spatial averaging in the superior colliculus related to goal computation.

More Related Videos

Using Saccadometry with Deep Brain Stimulation to Study Normal and Pathological Brain Function
05:44

Using Saccadometry with Deep Brain Stimulation to Study Normal and Pathological Brain Function

Published on: July 14, 2016

Characterizing the Relationship Between Eye Movement Parameters and Cognitive Functions in Non-demented Parkinson's Disease Patients with Eye Tracking
07:26

Characterizing the Relationship Between Eye Movement Parameters and Cognitive Functions in Non-demented Parkinson's Disease Patients with Eye Tracking

Published on: September 26, 2019

Related Experiment Videos

Last Updated: May 15, 2026

Investigating the Deployment of Visual Attention Before Accurate and Averaging Saccades via Eye Tracking and Assessment of Visual Sensitivity
06:46

Investigating the Deployment of Visual Attention Before Accurate and Averaging Saccades via Eye Tracking and Assessment of Visual Sensitivity

Published on: March 18, 2019

Using Saccadometry with Deep Brain Stimulation to Study Normal and Pathological Brain Function
05:44

Using Saccadometry with Deep Brain Stimulation to Study Normal and Pathological Brain Function

Published on: July 14, 2016

Characterizing the Relationship Between Eye Movement Parameters and Cognitive Functions in Non-demented Parkinson's Disease Patients with Eye Tracking
07:26

Characterizing the Relationship Between Eye Movement Parameters and Cognitive Functions in Non-demented Parkinson's Disease Patients with Eye Tracking

Published on: September 26, 2019

Area of Science:

  • Neuroscience
  • Cognitive Science
  • Ophthalmology

Background:

  • The global effect causes eye movements (prosaccades) to deviate towards intermediate positions.
  • Antisaccades, unlike prosaccades, involve separate stimulus and goal locations and show weaker collicular activity.

Purpose of the Study:

  • To investigate if the global effect arises from stimulus or goal computations.
  • To determine if the global effect is larger for antisaccades, consistent with collicular averaging models.

Main Methods:

  • Human subjects performed antisaccades with distractors near the stimulus or goal.
  • Prosaccades and antisaccades were performed with and without goal-related distractors.
  • Findings were compared with predictions from collicular models.

Main Results:

  • Global effects occurred only with goal-related distractors, not stimulus-related ones.
  • The global effect was 3-4 times larger for antisaccades than prosaccades after adjusting for response latency.
  • Results align with predictions from collicular spatial averaging models.

Conclusions:

  • The global effect in antisaccades supports spatial averaging within collicular maps.
  • This effect likely originates from neural activity related to goal representations, not stimulus representations.