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[Adverse event profile of new targeted agents for renal cell carcinoma]

Masahiro Nozawa1, Hirotsugu Uemura

  • 1The Department of Urology, Kinki University Faculty of Medicine.

Hinyokika Kiyo. Acta Urologica Japonica
|December 21, 2012
PubMed

Insights

Targeted therapies improve survival in advanced kidney cancer but cause side effects like hypertension. Managing these adverse events is crucial for maintaining treatment duration and patient care.

Area of Science:

  • Oncology
  • Pharmacology

Context:

  • Advanced renal cell carcinoma (RCC) treatment benefits from targeted therapy.
  • Treatment discontinuation due to intolerability is a significant challenge in advanced RCC.
  • Effective management of adverse events is essential for prolonged patient treatment.

Purpose:

  • To review the adverse-event profiles of emerging targeted therapies for renal cell carcinoma.
  • To highlight the importance of managing side effects for treatment adherence.

Summary:

  • Targeted therapies offer survival benefits for advanced renal cell carcinoma (RCC) patients.
  • Common adverse events include hypertension, fatigue, and gastrointestinal issues, often leading to treatment discontinuation.
  • This review examines the adverse-event profiles of several targeted agents under development for RCC, including axitinib, tivozanib, and others.

Impact:

  • Informs clinical decision-making regarding the selection and management of targeted therapies in RCC.
  • Highlights the need for strategies to mitigate adverse events and improve treatment adherence.
  • Guides the development of novel targeted agents with improved safety profiles for kidney cancer treatment.

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