GC for flavonoids analysis: Past, current, and prospective trends

Area of Science:

• Phytochemistry
• Analytical Chemistry
• Separation Science

Background:

• Flavonoids are abundant phytochemicals recognized for their significant health benefits, particularly against age-related diseases.
• Chromatography techniques are crucial for the separation and identification of flavonoids.
• Gas chromatography (GC) is a powerful tool for precise flavonoid measurement.

Purpose of the Study:

• To review the developments in the application of GC and MS for flavonoid determination over recent decades.
• To highlight the current state-of-the-art in GC-MS analysis of flavonoids.
• To discuss future trends and opportunities, including multidimensional GC analysis.

Main Methods:

• Review of scientific literature focusing on Gas Chromatography (GC) and Mass Spectrometry (MS) applications.
• Analysis of quantitative and qualitative methods for flavonoid determination using GC-MS.
• Exploration of advancements in separation science for phytochemical analysis.

Main Results:

• GC-MS offers a sensitive and accurate method for both quantitative and qualitative analysis of a wide range of flavonoids.
• Significant progress has been made in GC and MS techniques for flavonoid determination over the past decades.
• Multidimensional GC presents potential opportunities for enhanced flavonoid separation.

Conclusions:

• GC-MS is a vital technique for the comprehensive analysis of flavonoids.
• Continued development in GC technology, including multidimensional approaches, promises improved flavonoid determination.
• The review underscores the importance of advanced analytical techniques in understanding flavonoid health benefits.