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Updated: May 15, 2026

Studying Copper Nanoparticle-Induced Programmed Cell Death in Bacteria
Published on: May 16, 2025
Study of SOD mimic and nucleic acid interaction activity exerted by enrofloxacin-based copper(II) complexes
Mohan N Patel1, Bhupesh S Bhatt, Promise A Dosi
1Department of Chemistry, Sardar Patel University, Vallabh Vidyanagar - 388 120, Gujarat, India. jeenen@gmail.com
Abstract:
Five new copper(II) complexes of type [Cu(erx)(L)Cl] (erx, enrofloxacin; thiophene-2-carbaldehyde (L(1) ); pyridine-2-carbaldehyde (L(2) ); 2,2'-dipyridylamine (L(3) ); 4,5-diazafluoren-9-one (L(4) ); bis(3,5-dimethyl-1-pyrazolyl)methane (L(5) )) have been synthesized and characterized by elemental analysis, reflectance, IR, and FAB-MS. Complexes have been investigated for their interaction with calf thymus (CT) DNA utilizing the absorption-titration method, viscometric and DNA thermal denaturation studies. The cleavage reaction on pUC19 DNA has been monitored by agarose gel electrophoresis. The results indicated that the Cu(II) complexes can more effectively promote the cleavage of plasmid DNA at physiological pH and superoxide dismutase. The (SOD) activity of the complexes has been evaluated by the nitroblue tetrazolium assay, and the complexes catalyzed the dismutation of superoxide at pH 7.8 with IC(50) values of 0.35-1.25 μM. The complexes have also been screened for their antibacterial activity against five pathogenic bacteria.
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