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Nanoparticles for imaging and treating brain cancer.
Joseph D Meyers1, Tennyson Doane, Clemens Burda
1Departments of Biomedical Engineering & Radiology, Case Western Reserve University, Cleveland, OH 44106, USA.
Nanomedicine (London, England)
|December 22, 2012
Summary
Nanoparticles show promise for brain cancer treatment by exploiting the disrupted blood-brain-tumor barrier. This review highlights current successes and future potential for nanoparticle-based therapies against brain tumors.
Area of Science:
- Nanomedicine
- Oncology
- Neuroscience
Background:
- Brain cancer disrupts the blood-brain barrier, creating a blood-brain-tumor barrier.
- Nanoparticles (NPs) leverage increased vascular permeability seen in cancers.
- NPs accumulate in tumors due to impaired lymphatic drainage.
Purpose of the Study:
- To review the current applications of nanoparticles for brain cancer treatment.
- To provide an outlook on future developments in this field.
Main Methods:
- Review of existing laboratory and clinical research on nanoparticles for brain cancer.
- Analysis of nanoparticle behavior within the blood-brain-tumor barrier context.
Main Results:
- Nanoparticles demonstrate significant promise in preclinical and clinical settings for brain cancer.
- The unique properties of the blood-brain-tumor barrier can be exploited by NPs.
Conclusions:
- Nanoparticle research for brain cancer is an emerging field with substantial potential.
- The future of nanoparticle-based brain cancer therapies is promising.
