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Surgical Approach to Full Soft Tissue Face Allograft Procurement for Vascularized Composite Allotransplantation
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Published on: December 30, 2025

Free graft techniques in skull base reconstruction.

Jonathan Y Ting1, Ralph Metson

  • 1Department of Otolaryngology, Massachusetts Eye and Ear Infirmary and Department of Otology and Laryngology, Harvard Medical School, 243 Charles Street,Boston, MA 02114, USA. jonathan_ting@meei.harvard.edu

Advances in Oto-Rhino-Laryngology
|December 22, 2012
PubMed
Summary

Endoscopic surgery is now standard for skull base defects and CSF leaks. Free mucosal grafts from the nasal septum or turbinates offer a reliable, minimally invasive repair option.

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Published on: December 22, 2015

Area of Science:

  • Neurosurgery
  • Otolaryngology
  • Skull Base Surgery

Background:

  • Management of anterior skull base defects, CSF leaks, and encephaloceles has evolved.
  • A shift towards endoscopic, minimally invasive surgical approaches is evident over the past 20-30 years.

Purpose of the Study:

  • To review the efficacy of free mucosal grafts in repairing anterior skull base defects.
  • To highlight the advantages of endoscopic techniques for these repairs.

Main Methods:

  • Review of endoscopic surgical techniques for skull base defect repair.
  • Application of free mucosal grafts harvested from nasal septum or turbinates.
  • Single-layer and multi-layer reconstruction strategies for varying defect sizes.

Main Results:

  • Free mucosal grafts are effective for the majority of spontaneous or traumatic skull base defects.
  • Grafts can be harvested easily from nasal septum or turbinates.
  • High graft take rates are associated with this technique.

Conclusions:

  • Endoscopic, minimally invasive approaches are preferred for anterior skull base defects.
  • Free mucosal grafts provide an accessible, reliable, and popular method for reconstruction.
  • This technique is suitable for both small and large defects, offering a high success rate.