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Interleukin-18 induces insulin resistance in the hyperthyroid state

Shozo Miyauchi1, Bunzo Matsuura, Teruhisa Ueda

  • 1Department of Internal Medicine, Uwajima City Hospital, Uwajima, Ehime 798-8510, Japan. syozo@uwajima-mh.jp

Endocrine Journal
|December 22, 2012
PubMed

We previously reported that serum interleukin-18 (IL-18) levels were significantly increased in hyperthyroid Graves' disease patients. The development of insulin resistance in hyperthyroidism has been documented. We investigated the relationship between IL-18 and insulin resistance in patients with hyperthyroid Graves' disease and in experimental hyperthyroid mice. Then, we examined whether IL-18 induces insulin resistance in mice injected with IL-18 for a week. A significant positive correlation was observed between serum IL-18 levels and parameters such as thyroid functions and homeostasis model assessment for insulin resistance in hyperthyroid Graves' disease. In experimental hyperthyroid mice, IL-18 was significantly elevated. Insulin resistance increased in experimental hyperthyroid mice and IL-18-injected mice. These findings suggest IL-18 to be an important factor inducing insulin resistance in hyperthyroidism.

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