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Updated: May 15, 2026

Investigating Aortic Valve Calcification via Isolation and Culture of T Lymphocytes using Feeder Cells from Irradiated Buffy Coat
Published on: February 4, 2021
[Bicuspid aortic valve: epidemiology, genetics and clinics]
Lamia Ait-Ali1, Ilenia Foffa, Pierluigi Festa
1Istituto di Fisiologia Clinica, Consiglio Nazionale delle Ricerche, Pisa, Massa. aitlamia@ifc.cnr.it
Abstract:
Bicuspid aortic valve (BAV) is the most common congenital cardiac malformation, affecting 1-2% of the general population. BAV is frequently associated with significant aortic pathology (valve regurgitation, endocarditis, severe aortic stenosis, aortic aneurysm and dissection) accounting for considerable morbidity and mortality. Despite its clinical relevance, the pathogenesis of BAV disease and its complications remain largely unknown. The purpose of this paper is to discuss and summarize our current understanding of BAV in terms of epidemiology, genetics and clinics.
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