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Investigating Aortic Valve Calcification via Isolation and Culture of T Lymphocytes using Feeder Cells from Irradiated Buffy Coat
Published on: February 4, 2021
[Bicuspid aortic valve: epidemiology, genetics and clinics]
Lamia Ait-Ali1, Ilenia Foffa, Pierluigi Festa
1Istituto di Fisiologia Clinica, Consiglio Nazionale delle Ricerche, Pisa, Massa. aitlamia@ifc.cnr.it
Recenti Progressi in Medicina
|December 22, 2012
Summary
Bicuspid aortic valve (BAV), a common heart defect, is linked to serious aortic issues. This review covers BAV epidemiology, genetics, and clinical aspects, highlighting knowledge gaps in its development and complications.
Area of Science:
- Cardiology
- Genetics
- Congenital Malformations
Background:
- Bicuspid aortic valve (BAV) is the most prevalent congenital heart defect, impacting 1-2% of the population.
- BAV is associated with severe aortic pathologies, including stenosis, regurgitation, aneurysm, and dissection, leading to significant morbidity and mortality.
- The underlying pathogenesis of BAV and its associated complications remains poorly understood.
Purpose of the Study:
- To consolidate and review the current knowledge on bicuspid aortic valve.
- To discuss the epidemiology, genetics, and clinical manifestations of BAV.
- To identify areas requiring further research regarding BAV disease.
Main Methods:
- Literature review and synthesis of existing research.
- Epidemiological data analysis.
- Genetic association studies review.
- Clinical case reviews and outcome analysis.
Main Results:
- BAV prevalence and demographic distribution.
- Key genetic factors and inheritance patterns implicated in BAV.
- Spectrum of associated aortic diseases and their clinical impact.
- Current understanding of BAV pathophysiology.
Conclusions:
- BAV is a significant public health concern due to its high prevalence and association with life-threatening aortic conditions.
- Further research into the genetic and developmental pathways of BAV is crucial for understanding its pathogenesis.
- Comprehensive clinical management strategies are needed to address the diverse complications associated with BAV.
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