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Related Concept Videos

Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
Angle Closure Glaucoma: Treatment01:28

Angle Closure Glaucoma: Treatment

Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
Glaucoma: Overview01:25

Glaucoma: Overview

Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
Clinical Trials01:16

Clinical Trials

Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
There are four phases in a clinical trial. A phase one...

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Related Experiment Video

Updated: May 15, 2026

Three Different Protocols of Corneal Collagen Crosslinking in Keratoconus: Conventional, Accelerated and Iontophoresis
07:29

Three Different Protocols of Corneal Collagen Crosslinking in Keratoconus: Conventional, Accelerated and Iontophoresis

Published on: November 12, 2015

New clinical pathways for keratoconus.

D M Gore1, A J Shortt, B D Allan

  • 1Moorfields Eye Hospital, London, UK. dan.gore@moorfields.nhs.uk

Eye (London, England)
|December 22, 2012
PubMed
Summary
This summary is machine-generated.

New keratoconus treatments like corneal crosslinking and ring implants offer improved outcomes. These interventions focus on stabilizing corneal shape and rehabilitating vision, advancing patient management beyond traditional contact lenses and transplants.

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Last Updated: May 15, 2026

Three Different Protocols of Corneal Collagen Crosslinking in Keratoconus: Conventional, Accelerated and Iontophoresis
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Full-Field Optical Coherence Microscopy for Histology-Like Analysis of Stromal Features in Corneal Grafts
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Full-Field Optical Coherence Microscopy for Histology-Like Analysis of Stromal Features in Corneal Grafts

Published on: October 21, 2022

Area of Science:

  • Ophthalmology
  • Corneal Surgery
  • Vision Science

Background:

  • Traditional keratoconus management relied on rigid contact lenses and corneal transplantation.
  • Recent advancements have introduced novel surgical and therapeutic interventions.
  • Accumulated outcome data now support evaluating these newer treatment options.

Purpose of the Study:

  • To review the evidence base for emerging keratoconus interventions.
  • To define the role of new treatments in current management pathways.
  • To categorize interventions by their primary goal: corneal shape stabilization or visual rehabilitation.

Main Methods:

  • Systematic review of outcome data for recent keratoconus interventions.
  • Analysis of evidence for corneal collagen crosslinking.
  • Evaluation of intracorneal ring implantation, topographic phototherapeutic keratectomy, and phakic intraocular lens implantation.

Main Results:

  • Significant outcome data now exist for newer keratoconus treatments.
  • Interventions like corneal collagen crosslinking and intracorneal ring implantation show promise.
  • Topographic phototherapeutic keratectomy and phakic intraocular lenses also contribute to management.

Conclusions:

  • Modern keratoconus management incorporates shape stabilization and visual rehabilitation strategies.
  • Newer interventions offer alternatives to traditional methods for many patients.
  • Evidence supports integrating these advanced techniques into clinical practice.