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Related Concept Videos

Tumor Immunotherapy01:27

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
Cancer Vaccines01:30

Cancer Vaccines

Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Cytotoxic T Cells-mediated Immune Response01:27

Cytotoxic T Cells-mediated Immune Response

Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...

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Related Experiment Video

Updated: May 15, 2026

Tractable In Vivo Reprogramming of Tumor Cells to Type 1 Conventional Dendritic Cell-like Cells
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Tractable In Vivo Reprogramming of Tumor Cells to Type 1 Conventional Dendritic Cell-like Cells

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[Dendritic cells for cancer immunotherapy].

Kazuhiro Kakimi1, Atsushi Kondo, Hirokazu Matsushita

  • 1Department of Immunotherapeutics, The University of Tokyo Hospital.

Nihon Rinsho. Japanese Journal of Clinical Medicine
|December 25, 2012
PubMed
Summary

Dendritic cells (DCs) are key immune cells that initiate and regulate immune responses. Understanding their distinct subsets and functions is crucial for developing targeted immunotherapies.

Area of Science:

  • Immunology
  • Cell Biology

Context:

  • Dendritic cells (DCs) are crucial antigen-presenting cells (APCs) that initiate and regulate adaptive immunity.
  • Distinct DC subsets possess specialized functions, influencing the type and outcome of immune responses.
  • Understanding DC subsets is vital for comprehending antigen presentation via MHC class I and II pathways.

Purpose:

  • To elucidate the distinct phenotypes and functions of dendritic cell subsets.
  • To understand antigen uptake, processing, and presentation mechanisms by different DC subsets.
  • To identify surface receptors on DCs for targeted antigen delivery.

Summary:

  • Dendritic cells (DCs) are critical for initiating and regulating immune responses through antigen presentation.
  • Different DC subsets dictate the type of immune response, highlighting the importance of their specialized functions.

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Experimental Melanoma Immunotherapy Model Using Tumor Vaccination with a Hematopoietic Cytokine

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Tractable In Vivo Reprogramming of Tumor Cells to Type 1 Conventional Dendritic Cell-like Cells
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Tractable In Vivo Reprogramming of Tumor Cells to Type 1 Conventional Dendritic Cell-like Cells

Published on: August 1, 2025

Preparation of Tumor Antigen-loaded Mature Dendritic Cells for Immunotherapy
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Preparation of Tumor Antigen-loaded Mature Dendritic Cells for Immunotherapy

Published on: August 1, 2013

Experimental Melanoma Immunotherapy Model Using Tumor Vaccination with a Hematopoietic Cytokine
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Experimental Melanoma Immunotherapy Model Using Tumor Vaccination with a Hematopoietic Cytokine

Published on: February 24, 2023

  • Research focuses on understanding DC phenotypes, antigen processing for MHC presentation, and receptor-mediated targeting.

    • Impact:

    • Facilitates direct in vivo targeting of antigens to DC surface receptors, bypassing ex vivo manipulation.
    • Enables the development of novel dendritic cell immunotherapies, potentially combined with checkpoint inhibitors.
    • Advances the field of targeted immunotherapy by leveraging the specialized functions of DC subsets.