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Dieckol isolated from brown seaweed Ecklonia cava attenuates type ІІ diabetes in db/db mouse model
Min-Cheol Kang1, W A J P Wijesinghe, Seung-Hong Lee
1Department of Marine Life Sciences, Jeju National University, Jeju 690-756, Republic of Korea.
Abstract:
In the present study, the attenuation of type ІІ diabetes by dieckol, a phlorotannin derivative isolated from brown seaweed, Ecklonia cava was investigated in C57BL/KsJ-db/db, a type ІІ diabetes mouse model. Dieckol was administered intraperitoneal injection at doses of 10 and 20 mg/kg body weight diabetes mice for 14 days. The blood glucose level, serum insulin level and body weight were significantly reduced in the dieckol administered group, compared to that of the saline administered group. Furthermore, reduced thiobarbituric acid reactive substraces (TBARS), as well as increased activities of antioxidant enzymes, including superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSH-px) in liver tissues were observed in the dieckol administered group. In addition, increased levels of the phosphorylation of AMPK and Akt were observed in the muscle tissues of the dieckol administered group in a Western blotting analysis. According to the findings of this study, it could be suggested that, dieckol can be developed as a therapeutic agent for type ІІ diabetes.
Insights
Dieckol, a compound from brown seaweed, effectively reduced blood glucose and improved insulin levels in a type II diabetes mouse model. This natural compound also demonstrated significant antioxidant and metabolic benefits, suggesting its therapeutic potential.
Area of Science:
- Pharmacology
- Biochemistry
- Marine Natural Products
Background:
- Type II diabetes is a growing global health concern.
- Current treatments have limitations and side effects.
- Natural compounds offer potential therapeutic avenues.
Purpose of the Study:
- To investigate the anti-diabetic effects of dieckol, a phlorotannin from Ecklonia cava.
- To evaluate dieckol's impact on metabolic parameters and oxidative stress in a type II diabetes mouse model.
Main Methods:
- Administration of dieckol (10 and 20 mg/kg) via intraperitoneal injection to C57BL/KsJ-db/db mice for 14 days.
- Monitoring of blood glucose, serum insulin, and body weight.
- Assessment of thiobarbituric acid reactive substances (TBARS) and antioxidant enzyme activities (SOD, CAT, GSH-px) in liver tissues.
- Western blotting analysis for AMPK and Akt phosphorylation in muscle tissues.
Main Results:
- Dieckol significantly reduced blood glucose, serum insulin levels, and body weight compared to the control group.
- Dieckol administration led to decreased TBARS and increased antioxidant enzyme activities in the liver.
- Increased phosphorylation of AMPK and Akt was observed in the muscle tissues of dieckol-treated mice.
Conclusions:
- Dieckol exhibits significant anti-diabetic properties.
- Dieckol ameliorates hyperglycemia, oxidative stress, and modulates key metabolic signaling pathways.
- Dieckol holds promise as a potential therapeutic agent for type II diabetes management.
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