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Updated: May 15, 2026
06:15
Tumor Treating Field Therapy in Combination with Bevacizumab for the Treatment of Recurrent Glioblastoma
Published on: October 27, 2014
Cervical extravasation of bevacizumab
Johann Dréanic1, Romain Coriat, Olivier Mir
1Departments of Gastroenterology, Cochin Teaching Hospital, AP-HP, Sorbonne Paris Cité, Paris Descartes University, Paris, France.
Anti-Cancer Drugs
|December 25, 2012
Summary
Bevacizumab extravasation during chemotherapy is rare but can occur. This case report suggests that conservative, nonsurgical management may be effective for cervical extravasation, leading to full recovery.
Area of Science:
- Oncology
- Pharmacology
Background:
- Monoclonal antibodies like bevacizumab are standard cancer treatments.
- Management guidelines for bevacizumab extravasation are lacking.
- Extravasation incidence ranges from 0.5-6%.
Observation:
- An 86-year-old woman with metastatic colon cancer experienced bevacizumab extravasation due to catheter migration.
- Symptoms included cervical pain without skin changes, later developing a neck mass.
- CT scan confirmed a perijugular fluid collection.
Findings:
- Conservative management was initiated for the bevacizumab extravasation.
- The patient recovered completely from symptoms within three weeks.
Implications:
- Physicians should consider conservative management for bevacizumab extravasation.
- This approach may be effective, even in cases of cervical extravasation.
- Further research is needed to establish clear extravasation management protocols.
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