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Related Concept Videos

Proteoglycans01:05

Proteoglycans

Glycans, a class of complex heterogeneous molecules, can be covalently attached to proteins to form glycosylated proteins that regulate various physiological and pathological processes. Glycosylated proteins or glycoproteins comprise N-linked and O-linked oligosaccharides. O-glycosylation is the most common type of protein glycosylation. Here, glycans attach to the oxygen atom of the hydroxyl groups of Serine or Threonine residues. O-linked glycosylation occurs later in protein processing,...
Glycocalyx and its Functions01:14

Glycocalyx and its Functions

The glycocalyx is a carbohydrate-rich, fuzzy-appearing layer on the outer surface of the cell membrane. It is highly hydrophilic, because of this it attracts large amounts of water to the cell's surface. This aids the cell's interaction with the watery environment and also helps it to obtain substances dissolved in the water. It is also important for cell identification, self/non-self determination, and embryonic development and is used in cell-to-cell attachments to form tissues.
Components of...
Matrix Proteoglycans and Glycoproteins01:21

Matrix Proteoglycans and Glycoproteins

Proteoglycans are extensively glycosylated proteins, commonly found in the extracellular matrix, interwoven with collagen fibers. Hyaline cartilage, the most common type of cartilage in the body, consists of short and dispersed collagen fibers associated with large amounts of proteoglycans. These proteoglycans have long negative charges that attract cations, which in turn attract water molecules. This influx of ions and water molecules swells up the proteoglycan like a water-soaked gel that can...
Protein Glycosylation01:25

Protein Glycosylation

Glycosylation, the most common post-translational modification for proteins, serves diverse functions. Adding sugars to proteins makes the proteins more resistant to proteolytic digestion. Glycosylated proteins can act as markers and receptors to promote cell-cell adhesion. Additionally, they have many essential quality control functions in the cell, such as correct protein folding and facilitating transport of misfolded proteins to the cytosol, which can be degraded.
Glycosylation occurs in...
Immunoglobulin-like Cell Adhesion Molecules01:31

Immunoglobulin-like Cell Adhesion Molecules

Immunoglobulin-like cell adhesion molecules or Ig-CAMs are a versatile group of cell surface glycoproteins belonging to the immunoglobulin protein superfamily. Ig-CAMs possess the characteristic immunoglobulin protein domains and other domains such as the fibronectin type III domain. The Ig domains are glycosylated to varying degrees in different Ig-CAMs.
Ig-CAMs exhibit either homophilic binding (to other Ig-CAMs) or heterophilic binding (to other ligands such as integrins). While most Ig-CAMs...
Peptide Identification Using Tandem Mass Spectrometry01:33

Peptide Identification Using Tandem Mass Spectrometry

Tandem mass spectrometry, also known as MS/MS or MS2, is an analytical technique that employs two mass analyzers. Essentially it is a series of mass spectrometers that helps isolate a particular biomolecule and then helps study its chemical properties.
This technique helps gather information regarding the protein from which the peptide was obtained and to study the peptides’ amino acid sequence. Identifying peptides from a complex mixture is an important component of the growing field of...

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Development of a Backbone Cyclic Peptide Library as Potential Antiparasitic Therapeutics Using Microwave Irradiation
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Development of a Backbone Cyclic Peptide Library as Potential Antiparasitic Therapeutics Using Microwave Irradiation

Published on: January 26, 2016

Multivalent glyco(cyclo)peptides.

M Carmen Galan1, Pascal Dumy, Olivier Renaudet

  • 1School of Chemistry, University of Bristol, Cantock's Close, Bristol BS8 1TS, UK.

Chemical Society Reviews
|December 25, 2012
PubMed
Summary
This summary is machine-generated.

Researchers are advancing the study of carbohydrate-protein interactions using peptide-based scaffolds. This review highlights recent progress in creating and applying glycopeptides and glycocyclopeptides for biological research.

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Last Updated: May 15, 2026

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Area of Science:

  • Carbohydrate chemistry
  • Glycobiology
  • Supramolecular chemistry

Background:

  • Carbohydrate-protein interactions are crucial in biological processes.
  • Multivalent display of carbohydrates on cell surfaces is key.
  • Glycoclusters and glycodendrimers mimic this display.

Purpose of the Study:

  • To review recent advances in glycopeptide and glycocyclopeptide synthesis and applications.
  • To highlight the utility of peptide scaffolds in glycobiology.

Main Methods:

  • Focus on linear glycopeptides and glycocyclopeptides.
  • Utilizing peptide and cyclopeptide scaffolds for glycan presentation.

Main Results:

  • Peptides and cyclopeptides are effective scaffolds for multivalent glycan display.
  • Recent advances have expanded their preparation and utilization.

Conclusions:

  • Glycopeptides and glycocyclopeptides are valuable tools in glycobiology research.
  • Continued development of these molecules will further advance the field.