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Related Concept Videos

Laminins are the Adhesive Proteins of Basal Lamina00:55

Laminins are the Adhesive Proteins of Basal Lamina

Laminins are heterotrimeric proteins with high molecular mass found in the extracellular matrix. Each laminin molecule is composed of three chains, viz. alpha, beta, and gamma, coded by five, four, and three paralogous genes, respectively. Laminins are categories based on the compositions of the three chains.
In humans, the five forms of alpha chains are LAMA 1, LAMA 2, LAMA 3, LAMA 4, and LAMA 5. The four forms of beta chains are LAMB 1, LAMB 2, LAMB 3, and LAMB 4. The three forms of gamma...
Integrins01:10

Integrins

Animal and protozoan cells do not have cell walls to help maintain shape and provide structural stability. Instead, these eukaryotic cells secrete a sticky mass of carbohydrates and proteins into the spaces between adjacent cells. This network of proteins and molecules is called an extracellular matrix or ECM.
Some ECM proteins assemble into a basement membrane to which the remaining components adhere. Proteoglycans typically form the bulk of the ECM while fibrous proteins, like collagen,...
Basal Lamina are the Specialized Form of ECM01:03

Basal Lamina are the Specialized Form of ECM

The basal lamina is a thin extracellular layer that lies underneath the cells and separates them from other tissues. The three layers of the basal lamina are lamina lucida, lamina densa and lamina reticularis. The basal lamina, a mixture of glycoproteins and collagen, provides an attachment site for the epithelium, separating it from underlying connective tissue. The framework of basal lamina has other essential proteins such as laminins mesh, perlecan, entactin, and type IV collagen.
Proteins...
Type IV Collagen of Basal Lamina01:05

Type IV Collagen of Basal Lamina

Type IV collagen is a 400 nm long, network-forming collagen that acts as a barrier between the epithelial and endothelial cells. Type IV collagen  forms the backbone of the basement membrane by scaffolding with laminin, entactin, proteoglycans, and fibronectin. Apart from rendering structural support to the basement membrane, it also helps entail signaling potentials necessary for both pathological and physiological functions.
A type IV collagen molecule has six alpha chains which can exist in...
Selectins01:25

Selectins

Cell adhesion is  an essential aspect of multicellularity. While stable cell interactions usually occur between cells of the same type, transient cell interactions occur between cells of different tissue types, such as between neutrophils and endothelial cells. Selectins are one class of cell adhesion molecules (CAMs) that bind carbohydrate ligands to form transient cell adhesion. They are rod-like proteins with a long extracellular part of variable length ending with the lectin domain, which...
Anchoring Junctions01:03

Anchoring Junctions

Anchoring junctions are multiprotein complexes that help cells connect to other cells and the extracellular matrix. Anchoring junctions are present on the lateral and basal surfaces of cells, providing strong and flexible connections. Focal adhesions are often formed due to cell interactions with the ECM substrata, which initiate signal transduction via kinase cascades and other mechanisms. Together, they provide stability and tissue integrity. There are three types of anchoring junctions:...

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Related Experiment Video

Updated: May 15, 2026

Generating a Fractal Microstructure of Laminin-111 to Signal to Cells
06:56

Generating a Fractal Microstructure of Laminin-111 to Signal to Cells

Published on: September 28, 2020

The laminin family.

Monique Aumailley1

  • 1Center for Biochemistry, Medical Faculty, University of Cologne, Cologne, Germany. aumailley@uni-koeln.de

Cell Adhesion & Migration
|December 25, 2012
PubMed
Summary

Laminins are essential glycoproteins that form cellular networks, bridging cells and their environment. These proteins are critical for cell signaling, behavior, and the structure of basement membranes.

Area of Science:

  • Biochemistry
  • Cell Biology
  • Molecular Biology

Background:

  • Laminins are large glycoproteins composed of α, β, and γ polypeptide chains.
  • The human genome encodes 11 distinct laminin chains.
  • These chains assemble into diverse laminin variants with unique functions.

Purpose of the Study:

  • To summarize the structural diversity and functional importance of laminins.
  • To highlight the role of laminins in cellular networks and basement membrane architecture.

Main Methods:

  • Literature review of laminin structure and function.
  • Analysis of genomic data for laminin chain encoding.
  • Review of studies on laminin roles in cell-matrix interactions.

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A 3D Spheroid Model as a More Physiological System for Cancer-Associated Fibroblasts Differentiation and Invasion In Vitro Studies

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Generating a Fractal Microstructure of Laminin-111 to Signal to Cells
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Efficient Production and Purification of Recombinant Murine Kindlin-3 from Insect Cells for Biophysical Studies
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Main Results:

  • Laminins are formed by the assembly of three disulfide-linked polypeptide chains (α, β, γ).
  • Structural variations in domains lead to diverse laminin functions.
  • Laminins are crucial for connecting intracellular and extracellular compartments.

Conclusions:

  • Laminins are fundamental for cellular communication and behavior.
  • They play a vital role in maintaining the structural integrity and physiology of basement membranes.
  • Understanding laminin diversity is key to comprehending tissue architecture and function.