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Renal impairment in children with posterior urethral valves

Jameela Abdulaziz Kari1, Sherif El-Desoky, Youssef M K Farag

  • 1Department of Pediatrics, Faculty of Medicine, King Abdulaziz University, PO Box 80215, Jeddah 21589, Kingdom of Saudi Arabia. jkari@doctors.org.uk

Pediatric Nephrology (Berlin, Germany)
|December 25, 2012
PubMed

Insights

Posterior urethral valves (PUV) can lead to kidney failure in children. Early presentation and normal initial creatinine levels are key predictors of better renal outcomes in boys with PUV.

Area of Science:

  • Pediatric Nephrology
  • Urology
  • Medical Research

Background:

  • Posterior urethral valves (PUV) represent a significant cause of childhood end-stage renal disease.
  • Understanding predictors of renal impairment in PUV patients is crucial for improving long-term outcomes.

Purpose of the Study:

  • To characterize a cohort of pediatric patients diagnosed with posterior urethral valves (PUV).
  • To identify factors that predict the development of renal impairment in children with PUV.

Main Methods:

  • A retrospective chart review was conducted.
  • The study included boys with PUV treated at King Abdulaziz University hospital from 2002 to 2011.

Main Results:

  • The cohort consisted of 68 boys.
  • Longer follow-up duration, lower nadir serum creatinine, and lower last known serum creatinine were associated with renal impairment.
  • Follow-up duration was a significant predictor of serum creatinine doubling (OR, 1.8).

Conclusions:

  • Neither PUV ablation nor vesicostomy significantly impacted kidney function in this cohort.
  • Early presentation and normal nadir serum creatinine levels were associated with better renal outcomes in children with PUV.
Abstract

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