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Mast cells evaluation in meningioma of various grades
Joanna Reszec1, Adam Hermanowicz, Jan Kochanowicz
1Department of Medical Pathomorphology, Medical University of Bialystok, Bialystok, Poland. joasia@umwb.edu.pl
Abstract:
Meningioma is a heterogenous group of primary brain tumors. The progression or recurrence is relatively very common; however, prognostic factors which may indicate those events are not known. The aim of the study was to evaluate the presence of mast cells within the low grade and high grade meningiomas. The material included 70 cases of meningomas (63 G1 grade cases) of adult subjects (range 23-84 years). In paraffin sections presence of tryptase, a marker of mast cells, was detected by immunohistochemistry in 10 random fields in each slide under the light microscope. The presence of the peritumoral oedema was estimated by brain computer tomography. The expression of tryptase was observed in 32% of low grade meningiomas and 86% of high grade meningiomas. The immunostained cells were observed close to the blood vessels. We conclude that the number of mast cells might be a significant prognostic factor for the recurrence or bad prognosis of meningiomas.
Insights
Mast cells, identified by tryptase, are more prevalent in high-grade meningiomas. Their presence may indicate a higher risk of tumor recurrence or poor prognosis in patients with brain tumors.
Area of Science:
- Neuropathology
- Oncology
Background:
- Meningiomas are primary brain tumors with variable progression rates.
- Predictive factors for meningioma recurrence remain largely unknown.
- Understanding prognostic markers is crucial for patient management.
Purpose of the Study:
- To investigate the association between mast cell presence and meningioma grade.
- To evaluate mast cells as potential prognostic indicators for meningioma progression.
Main Methods:
- Immunohistochemistry was used to detect tryptase, a mast cell marker, in 70 meningioma samples.
- Samples included low-grade (G1) and high-grade meningiomas from adult patients.
- Peritumoral edema was assessed via brain computer tomography.
Main Results:
- Tryptase-positive mast cells were found in 32% of low-grade and 86% of high-grade meningiomas.
- Mast cells were frequently observed near blood vessels within the tumors.
- A higher mast cell presence correlated with higher-grade tumors.
Conclusions:
- Mast cell infiltration, indicated by tryptase expression, is significantly higher in high-grade meningiomas.
- The number of mast cells may serve as a valuable prognostic factor for predicting meningioma recurrence and outcomes.
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