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Updated: May 15, 2026

Enzymatic Synthesis of Epoxidized Metabolites of Docosahexaenoic, Eicosapentaenoic, and Arachidonic Acids
Published on: June 28, 2019
Cost-effective and Large-scale synthesis of 16:0 Lysophosphatidic Acid
James E East1, Timothy L Macdonald
1University of Virginia, Department of Chemistry, P.O. Box 400319, McCormick Road, Charlottesville, Virginia 22904.
Abstract:
Lysophosphatidic acid (LPA) is a bioactive compound that has gained attention due to its role in neoplastic diseases. Popularity of the compound has necessitated the use of large quantities of the phospholipid for in vivo and in vitro testing but methods for generating LPA require the use costly procedures, namely phosphoramidite coupling reagents. Additionally there has been no reported large-scale synthesis of LPA. In the present study we report the cost-effective and large-scale synthesis of 16:0 LPA.
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