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Updated: May 15, 2026

In Vivo Immunogenicity Screening of Tumor-Derived Extracellular Vesicles by Flow Cytometry of Splenic T Cells
Published on: September 23, 2021
Antigen shedding into the circulation contributes to tumor immune escape
1Institutes of Molecular Medicine and Experimental Immunology; University of Bonn; Bonn, Germany.
Abstract:
Tumors employ various mechanisms to escape elimination by the immune system. In addition to the local induction of immunosuppressive cell types such as regulatory T cells or myeloid derived suppressor cells, tumor antigen shedding into the circulation may suppress antitumor CD8(+) T-cell function via tolerogenic liver sinusoidal endothelial cells.
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