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[Inflammatory cancer].

P Romestaing1, J P Gérard, C Carrie

  • 1Service de radiothérapie, centre hospitalier Lyon-Sud, Pierre-Bénite.

La Revue Du Praticien
|April 1, 1990
PubMed
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Inflammatory breast cancer is a severe disease requiring systemic treatment, not primary surgery. While chemotherapy shows response rates, 5-year survival remains limited, prompting research into prognostic factors and novel therapies.

Area of Science:

  • Oncology
  • Medical Research

Context:

  • Inflammatory breast cancer (IBC) represents 1-4% of all breast cancers.
  • IBC is a highly aggressive form, primarily treated as a systemic disease.

Purpose:

  • To outline current treatment strategies for inflammatory breast cancer.
  • To discuss the challenges and future directions in managing this aggressive cancer.

Summary:

  • Initial treatment is systemic chemotherapy, with primary surgery contraindicated.
  • Objective response rates to chemotherapy range from 50-80%.
  • Local treatment (radiotherapy, surgery) depends on treatment response; 5-year survival is 30-48%.

Impact:

  • Identifies key areas for future research, including oncogenes and multidrug resistance (MDR) genes.

Related Experiment Videos

  • Highlights the potential of intensive chemotherapy with bone marrow transplantation and growth factors, pending further evaluation.