Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
Tumor Progression02:07

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Cancer02:18

Cancer

Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
Allosteric Proteins-ATCase01:19

Allosteric Proteins-ATCase

Binding sites linkages can regulate a protein's function.  For example, enzyme activity is often regulated through a feedback mechanism where the end product of the biochemical process serves as an inhibitor.
Aspartate transcarbamoylase (ATCase) is a cytosolic enzyme that catalyzes the condensation of L-aspartate and carbamoyl phosphate to  N-carbamoyl-L-aspartate. This reaction is the first step in pyrimidine biosynthesis. UTP and CTP, the end products of the pyrimidine synthesis pathway,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

SRW-YOLOv8n: a high-precision method for main-stem detection and clamping-point positioning of plug pepper seedlings.

Frontiers in plant science·2026
Same author

Electrochemical deoxygenative sulfenylation of aminopyrazoles with sodium sulfinates.

Chemical communications (Cambridge, England)·2026
Same author

Improved Outcomes with TKI Maintenance Following Brexucabtagene Autoleucel in Philadelphia-chromosome ALL.

Blood advances·2026
Same author

Outcomes of Tocilizumab for Cytokine Release Syndrome After Post-Transplant Cyclophosphamide.

Transplantation and cellular therapy·2026
Same author

Accurate 3D recording: Integrating ground-based LiDAR data and 3D segmentation network to extract 3D traits and analyze genetics in wheat populations.

Plant phenomics (Washington, D.C.)·2026
Same author

Electrochemically Enabled Sulfenylation of Imidazo[1,2-<i>a</i>]pyridines Using Sodium Sulfinates.

The Journal of organic chemistry·2026

Related Experiment Video

Updated: May 15, 2026

Adaptation of Semiautomated Circulating Tumor Cell (CTC) Assays for Clinical and Preclinical Research Applications
14:14

Adaptation of Semiautomated Circulating Tumor Cell (CTC) Assays for Clinical and Preclinical Research Applications

Published on: February 28, 2014

ACTB in cancer.

Chunmei Guo1, Shuqing Liu, Jiasheng Wang

  • 1Department of Biotechnology, Dalian Medical University, Dalian 116044, China.

Clinica Chimica Acta; International Journal of Clinical Chemistry
|December 26, 2012
PubMed
Summary
This summary is machine-generated.

Beta-actin (ACTB), once a standard reference gene, is now recognized as a key player in various cancers. Its abnormal expression is linked to tumor invasiveness and metastasis, necessitating further research.

More Related Videos

Cell-Based Drug Screening for Inhibitors of Autophagy Related 4B Cysteine Peptidase
09:51

Cell-Based Drug Screening for Inhibitors of Autophagy Related 4B Cysteine Peptidase

Published on: June 30, 2023

Associated Chromosome Trap for Identifying Long-range DNA Interactions
14:49

Associated Chromosome Trap for Identifying Long-range DNA Interactions

Published on: April 23, 2011

Related Experiment Videos

Last Updated: May 15, 2026

Adaptation of Semiautomated Circulating Tumor Cell (CTC) Assays for Clinical and Preclinical Research Applications
14:14

Adaptation of Semiautomated Circulating Tumor Cell (CTC) Assays for Clinical and Preclinical Research Applications

Published on: February 28, 2014

Cell-Based Drug Screening for Inhibitors of Autophagy Related 4B Cysteine Peptidase
09:51

Cell-Based Drug Screening for Inhibitors of Autophagy Related 4B Cysteine Peptidase

Published on: June 30, 2023

Associated Chromosome Trap for Identifying Long-range DNA Interactions
14:49

Associated Chromosome Trap for Identifying Long-range DNA Interactions

Published on: April 23, 2011

Area of Science:

  • Oncology
  • Molecular Biology
  • Biochemistry

Background:

  • Beta-actin (ACTB) is traditionally used as a housekeeping reference gene in cancer research.
  • Emerging evidence links ACTB dysregulation to numerous cancer types, including liver, lung, and breast cancers.
  • ACTB is frequently upregulated in tumor cells and tissues.

Purpose of the Study:

  • To review the multifaceted roles of beta-actin (ACTB) in tumorigenesis.
  • To explore the mechanisms underlying ACTB dysregulation in various cancers.
  • To integrate current knowledge and suggest future research directions for ACTB in oncology.

Main Methods:

  • Literature review of studies investigating beta-actin (ACTB) expression and function in cancer.
  • Analysis of data on ACTB deregulation across different tumor types.
  • Synthesis of findings related to ACTB's impact on cancer cell behavior.

Main Results:

  • Beta-actin (ACTB) is abnormally expressed and frequently upregulated in a wide spectrum of human cancers.
  • Altered ACTB expression and polymerization impact the actin cytoskeleton, affecting cancer cell invasiveness and metastasis.
  • Specific mechanisms driving ACTB dysregulation in tumors are being elucidated.

Conclusions:

  • Beta-actin (ACTB) is not merely a housekeeping gene but an active contributor to cancer progression.
  • Understanding ACTB's role in cytoskeletal dynamics is crucial for cancer treatment strategies.
  • Further investigation into ACTB mechanisms is warranted to explore its therapeutic potential.