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Infantile hemangiomas: an update on pathogenesis and therapy
Tina S Chen1, Lawrence F Eichenfield, Sheila Fallon Friedlander
1Pediatric Dermatology, Rady Children’s Hospital San Diego, San Diego, California, USA. tina.chen@gmail.com
Pediatrics
|December 26, 2012
Summary
Infantile hemangiomas (IHs), common in infants, can cause disfigurement or functional issues. New understanding and treatments like propranolol improve management to minimize long-term effects.
Area of Science:
- Pediatric Vascular Anomalies
- Dermatology
- Developmental Biology
Background:
- Infantile hemangiomas (IHs) are the most frequent vascular tumors in infants, impacting approximately 5% of newborns.
- While most IHs resolve naturally, some can lead to significant cosmetic, functional, or life-threatening complications.
Observation:
- Recent advancements in understanding hemangioma pathogenesis are refining diagnostic and therapeutic strategies.
- Specific IH subtypes, like segmental IH, are associated with detrimental structural anomalies.
- Established standards of care for IH evaluation and management have evolved significantly.
Findings:
- Novel therapeutic options, including oral propranolol, offer improved outcomes for IH treatment.
- These new treatments can mitigate medical risks and scarring associated with infantile hemangiomas.
Implications:
- Timely recognition and intervention are crucial for minimizing long-term sequelae of infantile hemangiomas.
- Caregivers and clinicians must carefully weigh the risk-benefit profile of new therapies like propranolol before initiating treatment.
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