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The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
11:39

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Published on: July 11, 2013

Topical therapies for atopic dermatitis.

Yoo Sang Baek1, Emily Henkel2, Lawrence F Eichenfield2

  • 1Departments of Dermatology and Pediatrics, University of California San Diego School of Medicine and Rady Children's Hospital, San Diego, California; Department of Dermatology, Guro Hospital, Korea University College of Medicine, Seoul, Republic of Korea.

Journal of the American Academy of Dermatology
|May 28, 2026
PubMed
Summary
This summary is machine-generated.

Topical therapies are key for managing atopic dermatitis. Approved options like corticosteroids and JAK inhibitors offer varied efficacy and safety, with potential for combination use in clinical practice.

Keywords:
atopic dermatitiscalcineurin inhibitorscorticosteroidcrisaboroleroflumilastruxolitinibtapinaroftopical

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Area of Science:

  • Dermatology
  • Pharmacology

Background:

  • Topical therapies are the primary treatment for atopic dermatitis.
  • Current US Food and Drug Administration-approved options include corticosteroids, calcineurin inhibitors, PDE4 inhibitors, JAK inhibitors, and AHR agonists.

Purpose of the Study:

  • To review the landscape of topical therapies for atopic dermatitis.
  • To highlight the different indications, efficacy, and safety profiles of approved agents.
  • To discuss the clinical practice of using multiple topical agents.

Main Methods:

  • Literature review of US Food and Drug Administration-approved topical therapies for atopic dermatitis.
  • Analysis of clinical practice patterns regarding combination or sequenced topical agent use.

Main Results:

  • Multiple classes of topical agents are approved for atopic dermatitis management.
  • Each agent class has distinct indications, efficacy, and safety considerations.
  • Clinical practice often involves using multiple agents concurrently or sequentially, beyond single-agent studies.

Conclusions:

  • A diverse range of topical therapies are available for atopic dermatitis.
  • Understanding individual agent profiles is crucial for effective management.
  • The practical application of topical treatments may involve complex regimens beyond standard study designs.