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Growth Assessment in Children Under 12 Years With Moderate-to-Severe Atopic Dermatitis Included in the PEDISTAD
Amy S Paller1, Alan D Irvine2, Eulalia Baselga3
1Departments of Dermatology and Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Insights
Children with moderate-to-severe atopic dermatitis (AD) show lower average height and higher weight and BMI compared to the general population. This real-world study highlights growth differences in pediatric AD patients.
Area of Science:
- Pediatric Dermatology
- Growth and Development
- Atopic Dermatitis Research
Background:
- Moderate-to-severe atopic dermatitis (AD) is a multifactorial condition.
- The disease burden of AD may impact children's physical growth.
- Understanding growth patterns in pediatric AD is crucial.
Purpose of the Study:
- To compare the height, weight, and BMI of children under 12 with moderate-to-severe AD to the general population.
- To identify potential growth deficits or alterations in pediatric AD patients.
- To provide real-world data on growth parameters in this cohort.
Main Methods:
- Cross-sectional analysis of enrollment data from the PEDISTAD study.
- Inclusion of pediatric patients (<12 years old) diagnosed with moderate-to-severe AD.
- Comparison of anthropometric data (height, weight, BMI) against general population percentiles.
Main Results:
- In children aged 5 to <12 years, a significant percentage were below the 50th percentile for height (72% males, 53% females).
- Conversely, weight was above the 50th percentile for a majority of children in this age group (56% males, 52% females), leading to above-average BMI.
- In younger children (0 to <5 years), height and weight percentiles varied, with a notable proportion above the 50th percentile for females.
Conclusions:
- Children aged 5 to <12 years with moderate-to-severe AD exhibit lower average height compared to the US 50th percentile, particularly males.
- Higher weight and consequently higher BMI were observed in the studied pediatric AD population.
- These findings underscore the impact of moderate-to-severe AD on growth parameters in children.
Background/Objective:
The multifactorial disease burden of moderate-to-severe atopic dermatitis (AD) may affect children's growth. We report height, weight, and body mass index (BMI) of children under 12 years old with moderate-to-severe AD in comparison to the general population.
Methods:
This was a cross-sectional analysis of enrollment data from PEDISTAD, a global real-world observational study of pediatric patients < 12 years old with moderate-to-severe AD.
Results:
Among the 1329 children with moderate-to-severe AD, 72% of male children 5 to < 12 years were below the 50th percentile for height, as were 53% of females in this age group. In contrast, the weight of children 5 to < 12 years was above the 50th percentile in 56% of males and 52% of females, resulting in above-average BMI values. In the 0 to < 5 years old age groups, height and weight were above the 50th percentile for 59% and 50% of female children, and 52% and 42% of male children, respectively.
Conclusions:
This real-world observational study showed in children 5 to < 12 years old with moderate-to-severe AD that the average height was lower than the US 50th percentile, with a more pronounced reduction in male children. Additionally, higher weight and, as a result, higher BMI were observed in the children included in this analysis.
Trial Registration:
ClinicalTrials.gov identifier: NCT03687359.
