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Growth Assessment in Children Under 12 Years With Moderate-to-Severe Atopic Dermatitis Included in the PEDISTAD
Amy S Paller1, Alan D Irvine2, Eulalia Baselga3
1Departments of Dermatology and Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Background/Objective:
The multifactorial disease burden of moderate-to-severe atopic dermatitis (AD) may affect children's growth. We report height, weight, and body mass index (BMI) of children under 12 years old with moderate-to-severe AD in comparison to the general population.
Methods:
This was a cross-sectional analysis of enrollment data from PEDISTAD, a global real-world observational study of pediatric patients < 12 years old with moderate-to-severe AD.
Results:
Among the 1329 children with moderate-to-severe AD, 72% of male children 5 to < 12 years were below the 50th percentile for height, as were 53% of females in this age group. In contrast, the weight of children 5 to < 12 years was above the 50th percentile in 56% of males and 52% of females, resulting in above-average BMI values. In the 0 to < 5 years old age groups, height and weight were above the 50th percentile for 59% and 50% of female children, and 52% and 42% of male children, respectively.
Conclusions:
This real-world observational study showed in children 5 to < 12 years old with moderate-to-severe AD that the average height was lower than the US 50th percentile, with a more pronounced reduction in male children. Additionally, higher weight and, as a result, higher BMI were observed in the children included in this analysis.
Trial Registration:
ClinicalTrials.gov identifier: NCT03687359.
