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Multichannel Extracellular Recording in Freely Moving Mice
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Multichannel Extracellular Recording in Freely Moving Mice

Published on: May 26, 2023

High-density microelectrode array recordings and real-time spike sorting for closed-loop experiments: an emerging

Felix Franke1, David Jäckel, Jelena Dragas

  • 1Department of Biosystems Science and Engineering, ETH Zürich Basle, Switzerland.

Frontiers in Neural Circuits
|December 26, 2012
PubMed
Summary

New technologies combining high-density microelectrode arrays and real-time spike sorting enable studying neural plasticity in thousands of neurons. This advances understanding of neural network development and function.

Keywords:
closed-loopmultielectrode arraysneural culturesreal-timespike sorting

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Real-time Electrophysiology: Using Closed-loop Protocols to Probe Neuronal Dynamics and Beyond
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Recording and Analyzing Multimodal Large-Scale Neuronal Ensemble Dynamics on CMOS-Integrated High-Density Microelectrode Array
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Recording and Analyzing Multimodal Large-Scale Neuronal Ensemble Dynamics on CMOS-Integrated High-Density Microelectrode Array

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Real-time Electrophysiology: Using Closed-loop Protocols to Probe Neuronal Dynamics and Beyond

Published on: June 24, 2015

Area of Science:

  • Neuroscience
  • Biotechnology

Background:

  • Neural plasticity is crucial for understanding brain development and function.
  • Current methods like intracellular recording are limited to small numbers of neurons.
  • Extracellular recording allows larger scale recordings but requires complex spike sorting.

Purpose of the Study:

  • To review recent technological advancements in neural recording and analysis.
  • To propose a combined approach for studying large-scale neural networks.

Main Methods:

  • Development of CMOS-based high-density microelectrode arrays for extracellular recording and stimulation.
  • Advancements in real-time spike sorting algorithms.

Main Results:

  • These technologies, when integrated, overcome limitations of traditional methods.
  • The combined approach facilitates simultaneous recording and stimulation of thousands of neurons in vitro.

Conclusions:

  • The integration of high-density microelectrode arrays and real-time spike sorting offers a powerful tool for in vitro neural network research.
  • This advancement will significantly enhance the study of neural plasticity in complex neural systems.