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Related Concept Videos

Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...

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A Melanoma Patient-Derived Xenograft Model
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Desmoplastic melanoma: a review.

Lucy L Chen1, Natalia Jaimes, Christopher A Barker

  • 1Dermatology Service, Memorial Sloan-Kettering Cancer Center, New York, New York 10022, USA.

Journal of the American Academy of Dermatology
|December 27, 2012
PubMed
Summary

Desmoplastic melanoma (DM), a rare spindle cell cancer, is challenging to diagnose due to its appearance and location. This review clarifies diagnostic features, subtypes, and management of pure versus mixed DM.

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Area of Science:

  • Dermatology
  • Oncology
  • Pathology

Background:

  • Desmoplastic melanoma (DM) is a rare variant of spindle cell melanoma.
  • It commonly affects sun-damaged skin in older individuals and is often amelanotic.
  • DM presents diagnostic challenges due to its predominantly dermal component and potential to mimic other spindle cell tumors.

Purpose of the Study:

  • To review the diagnostic features of desmoplastic melanoma.
  • To differentiate between pure and mixed histologic subtypes of DM.
  • To discuss risk factors, prognostic indicators, and current management strategies for DM.

Main Methods:

  • Literature review focusing on diagnostic criteria and classification of DM.
  • Analysis of variations in cellularity, fibrosis, and perineural invasion.
  • Comparison of pure (>90% desmoplastic) and mixed DM subtypes.

Main Results:

  • DM exhibits significant variability in cellularity, fibrosis, and perineural invasion.
  • Two subtypes, pure and mixed DM, are recognized based on the extent of desmoplastic features.
  • Accurate histological distinction is crucial for appropriate patient management.

Conclusions:

  • Desmoplastic melanoma presents diagnostic difficulties both clinically and histologically.
  • Understanding the distinction between pure and mixed DM is essential for accurate diagnosis and treatment.
  • Further research into risk, prognosis, and optimal management of DM is warranted.