Related Experiment Video
Updated: May 15, 2026

Isolating Human Peripheral Blood Mononuclear Cells and CD4+ T cells from Sézary Syndrome Patients for Transcriptomic Profiling
Published on: October 14, 2021
Actinic reticuloid imitating Sézary syndrome
David Pacheco1, Ana Fraga, Ana Rita Travassos
1Serviço de Dermatologia, Hospital de Santa Maria-Centro Hospitalar Lisboa Norte, Lisbon, Portugal. pachecocas@hotmail.com
Abstract:
Actinic reticuloid is a rare chronic idiopathic photosensitive dermatosis belonging to the spectrum of chronic actinic dermatitis and may be mistaken for cutaneous T-cell lymphoma. We report the case of an erythrodermic patient, initially diagnosed with Sézary syndrome, treated with chlorambucil and prednisolone. Later on, a photobiological study demonstrated photosensitivity to UVB, UVA, and visible light. The clinical picture, histological findings resembling lymphoma, and the results of the photobiological study established the diagnosis of actinic reticuloid. Currently the patient is avoiding sun exposure and being medicated with azathioprine and prednisolone, and is showing sustained improvement.
Related Concept Videos
Acne Infection
Skin Cancer
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Reticular Dermis
Reticular Layer
Underlying the papillary layer is the much thicker reticular layer, composed of dense, irregular connective...
Staphylococcal Skin Infections
Skin Diseases and Disorders
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Papillary Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
The papillary layer is made of loose, areolar connective tissue, which means the collagen and...
