Related Experiment Video
Updated: May 15, 2026

Non-invasive Skeletal Muscle Quantification in Small Animals Using Micro-computed Tomography
Published on: November 8, 2024
[Skeletal aging]
1National Center for Geriatrics and Gerontology, Japan.
Abstract:
Skeletal aging means aging of calcified bone matrix. Although calcification is an essential part of bone formation and its strength, in case of calcium deficiency, calcium is mobilized from bone at the expense of skeletal integrity. The quality as well as quantity of bone matrix is maintained through remodeling activity collaboratively performed by osteoclasts, osteoblasts and osteocytes, and remodeling disorder results in compromised bone strength. Energy homeostasis and vascular system are also closely linked with bone metabolism.
Related Concept Videos
The Effect of Aging on Tissues
Bone Disorders
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Changes in the Appendicular Skeleton with Age
Initially, the limb buds consist of a core of mesenchyme covered by a layer of ectoderm. The ectoderm at the end of the limb bud thickens to form a narrow crest called the apical ectodermal ridge. This ridge stimulates the underlying...
The Functions of the Skeletal System
Aging
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
What is the Skeletal System?

