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Related Concept Videos

Cellular Adaptation I: Introduction and Atrophy01:23

Cellular Adaptation I: Introduction and Atrophy

Cells can adapt to environmental changes to maintain function and avoid injury, a process called cellular adaptation. Adapted cells exist in a reversible intermediate state with changes in size, number, phenotype, metabolism, or function. These responses help cells meet altered physiological or pathological demands; for example, enlargement of breast and uterine tissues during pregnancy. Early adaptations may enhance function, but persistent stress eventually causes tissue damage.Types of...
The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
Changes in the Appendicular Skeleton with Age01:09

Changes in the Appendicular Skeleton with Age

The upper and lower limb initially develops as a small bulge called a limb bud, which appears on the lateral side of the early embryo. The upper limb bud appears near the end of the fourth week of development, with the lower limb bud appearing shortly after.
Initially, the limb buds consist of a core of mesenchyme covered by a layer of ectoderm. The ectoderm at the end of the limb bud thickens to form a narrow crest called the apical ectodermal ridge. This ridge stimulates the underlying...
Skeletal Muscle Anatomy00:55

Skeletal Muscle Anatomy

Skeletal muscle is the most abundant type of muscle in the body. Tendons are the connective tissue that attaches skeletal muscle to bones. Skeletal muscles pull on tendons, which in turn pull on bones to carry out voluntary movements.
Cellular Adaptation II: Hypertrophy01:26

Cellular Adaptation II: Hypertrophy

Hypertrophy is the increase in the size of individual cells, resulting in the enlargement of a tissue or organ. Unlike hyperplasia, which involves an increase in cell number, hypertrophy is characterized by an increase in cell volume. This process often occurs in response to higher functional demand or hormonal stimulation, leading to the production of more structural proteins and organelles, thereby enhancing the cells' work capacity.There are two primary types of hypertrophy: physiological...
Overview of Skeletal Muscle01:15

Overview of Skeletal Muscle

Skeletal muscles are composed of a bundle of muscle fibers and are attached to bones through tendons. Each skeletal muscle fiber is a single muscle cell. The sarcolemma, the plasma membrane of a skeletal muscle cell, consists of a lipid bilayer and glycocalyx that supports muscle fibers. The sarcolemma extends into the muscle cells to form tubular structures called transverse or T-tubules. Each side of the T-tubules consists of a membrane-bound structure called the sarcoplasmic reticulum,...

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The Creation of a Rat Model for Osteosarcopenia via Ovariectomy
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The Creation of a Rat Model for Osteosarcopenia via Ovariectomy

Published on: February 21, 2025

[Approaches to sarcopenia].

Sumito Ogawa1, Yasuyoshi Ouchi

  • 1Department of Geriatric Medicine, The University of Tokyo, Japan.

Clinical Calcium
|December 27, 2012
PubMed
Summary
This summary is machine-generated.

Preventing frailty and sarcopenia in older adults is crucial. Interventions like nutrition, medication, and exercise show promise for treating sarcopenia, a condition linked to aging.

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Segmentation and Linear Measurement for Body Composition Analysis using Slice-O-Matic and Horos
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Last Updated: May 15, 2026

The Creation of a Rat Model for Osteosarcopenia via Ovariectomy
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Published on: February 21, 2025

Segmentation and Linear Measurement for Body Composition Analysis using Slice-O-Matic and Horos
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Segmentation and Linear Measurement for Body Composition Analysis using Slice-O-Matic and Horos

Published on: March 21, 2021

Area of Science:

  • Gerontology and geriatric medicine
  • Muscle physiology and aging research

Context:

  • Frailty is a key component of geriatric syndromes.
  • Sarcopenia presents a significant challenge in the elderly population.
  • Understanding the multifactorial causes of sarcopenia is essential.

Purpose:

  • To summarize current understanding of sarcopenia's etiology.
  • To explore potential therapeutic strategies for sarcopenia.

Summary:

  • Sarcopenia, a condition characterized by muscle loss in aging, is influenced by factors including hormonal changes, malnutrition, and inflammation.
  • Nutritional support, pharmacological treatments, and exercise regimens are identified as promising interventions.

Impact:

  • Highlights the importance of addressing sarcopenia in geriatric care.
  • Provides a basis for developing targeted interventions to improve elderly health and mobility.