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Related Concept Videos

Allergic Reactions02:06

Allergic Reactions

Overview
Skin Diseases and Disorders01:23

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Allergic Reactions: Anaphylaxis01:30

Allergic Reactions: Anaphylaxis

Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin, heparin),...
Allergic Drug Reactions01:27

Allergic Drug Reactions

Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing numerous...
Reticular Dermis01:15

Reticular Dermis

The papillary and reticular dermis are the two layers of the dermis. They are made of connective tissue with fibers of collagen extending from one to the other, making the border between the two somewhat indistinct. The dermal papillae extending into the epidermis belong to the papillary layer, whereas the dense collagen fiber bundles below belong to the reticular layer.
Reticular Layer
Underlying the papillary layer is the much thicker reticular layer, composed of dense, irregular connective...
Papillary Dermis01:11

Papillary Dermis

Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
The papillary layer is made of loose, areolar connective tissue, which means the collagen and...

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Resolving Water, Proteins, and Lipids from In Vivo Confocal Raman Spectra of Stratum Corneum through a Chemometric Approach
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Published on: September 26, 2019

Dermatology for the allergist.

Dennis Kim1, Richard Lockey

  • 1Division of Allergy and Immunology, Department of Internal Medicine, University of South Florida College of Medicine and James A. Haley Veterans' Administration Hospital, Tampa, Florida.

The World Allergy Organization Journal
|December 27, 2012
PubMed
Summary
This summary is machine-generated.

Allergists and immunologists encounter various skin conditions. This review covers common dermatologic issues, differentiating those with immunologic causes from those without.

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Area of Science:

  • Dermatology
  • Immunology

Background:

  • Allergists/immunologists manage a spectrum of skin disorders.
  • These conditions range from immunologically driven diseases to those without an apparent immune basis.

Purpose of the Study:

  • To review select dermatologic conditions frequently seen by allergists/immunologists.
  • To differentiate between immunologic and non-immunologic skin disorders.

Main Methods:

  • Literature review of common dermatologic problems.
  • Categorization of skin disorders based on immunologic involvement.

Main Results:

  • Identified common skin disorders encountered in allergy/immunology practice.
  • Distinguished conditions like atopic dermatitis (immunologic) from rosacea (non-immunologic).

Conclusions:

  • Allergists/immunologists must recognize diverse dermatologic presentations.
  • Understanding the immunologic basis is crucial for managing certain skin conditions.