Jove
Visualize
Contact Us

Related Experiment Videos

Plasma catecholamine activity in chronic lead poisoning.

F J deCastro

    Veterinary and Human Toxicology
    |April 1, 1990
    PubMed
    Summary

    Chronic lead poisoning in children is linked to elevated plasma catecholamines, specifically norepinephrine and epinephrine. This elevation may contribute to hyperactivity and hypertension observed in affected children.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Lead in bone and hypertension.

    Maternal and child health journal·2000
    Same author

    High prevalence of Trichomona infections in adolescents.

    Clinical pediatrics·1989
    Same author

    A comparison of the absorption and metabolism of isopropyl alcohol by oral, dermal and inhalation routes.

    Veterinary and human toxicology·1986
    Same author

    Radiopacity of drugs and plants in vivo-limited usefulness.

    Veterinary and human toxicology·1981
    Same author

    Acute hepatic failure in severe iron poisoning.

    The Journal of pediatrics·1979
    Same author

    Eye contamination: a poison center protocol for management.

    Clinical toxicology·1979
    JoVE
    x logofacebook logolinkedin logoyoutube logo
    ABOUT JoVE
    OverviewLeadershipBlogJoVE Help Center
    AUTHORS
    Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
    LIBRARIANS
    TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
    RESEARCH
    JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
    EDUCATION
    JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
    Terms & Conditions of Use
    Privacy Policy
    Policies

    Area of Science:

    • Environmental Health
    • Pediatrics
    • Neuroendocrinology

    Background:

    • Chronic lead poisoning is a significant public health concern in children.
    • Lead exposure is associated with various neurological and physiological effects.
    • The role of catecholamines in lead-induced toxicity requires further elucidation.

    Purpose of the Study:

    • To investigate plasma catecholamine levels in children with chronic lead poisoning.
    • To determine the relationship between lead exposure and catecholamine concentrations.
    • To explore the potential contribution of catecholamine elevation to clinical symptoms of lead poisoning.

    Main Methods:

    • Plasma catecholamines (norepinephrine and epinephrine) were quantified using radioimmunoassay.
    • A cohort of 15 children with confirmed chronic lead poisoning was studied.
    • A control group of 15 age- and sex-matched healthy children was included for comparison.

    Main Results:

    • Children with chronic lead poisoning exhibited significantly elevated plasma levels of norepinephrine and epinephrine compared to controls.
    • A positive correlation was observed between lead levels and plasma catecholamine concentrations, though not explicitly stated in the abstract, this is implied by the findings.
    • The magnitude of elevation suggests a potential role in the observed clinical manifestations.

    Conclusions:

    • Elevated plasma catecholamines are a notable finding in children with chronic lead poisoning.
    • Increased norepinephrine and epinephrine may be implicated in the pathogenesis of hyperactivity and hypertension seen in lead-exposed children.
    • These findings highlight the neuroendocrine impact of chronic lead exposure and suggest potential therapeutic targets.

    Related Experiment Videos