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Updated: May 15, 2026

Synthesis of Soft Polysiloxane-urea Elastomers for Intraocular Lens Application

Synthesis of Soft Polysiloxane-urea Elastomers for Intraocular Lens Application

Published on: March 8, 2019

Silicone hydrogel lens-solution interaction and inflammation.

Nicole Carnt¹, Fiona Stapleton

¹Moorfields Eye Hospital, NHS Foundation Trust, London, United Kingdom. nicolecarnt@gmail.com

Eye & Contact Lens

|December 29, 2012

Summary

This summary is machine-generated.

Daily wear of silicone hydrogel (SiHy) contact lenses can cause eye inflammation through mechanical, allergic, or pathogen-driven pathways. This review explores inflammation models related to SiHy lens materials and care solutions.

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Last Updated: May 15, 2026

Synthesis of Soft Polysiloxane-urea Elastomers for Intraocular Lens Application

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Published on: March 8, 2019

Development of an In Vitro Ocular Platform to Test Contact Lenses

Development of an In Vitro Ocular Platform to Test Contact Lenses

Published on: April 6, 2016

Area of Science:

Ophthalmology and Vision Science
Biomaterials Science

Background:

Silicone hydrogel (SiHy) contact lenses are widely used for daily wear.
Their use with standard care solutions can lead to varying degrees of anterior eye inflammation.
Understanding the causes of this inflammation is crucial for improving contact lens safety and patient comfort.

Purpose of the Study:

To discuss the different pathways contributing to corneal and conjunctival inflammation associated with SiHy lens wear.
To examine the evidence supporting mechanical, allergic, and pathogen-driven models of inflammation.
To analyze these inflammation models in relation to SiHy lens properties and care solution compositions.

Main Methods:

Literature review and synthesis of existing research.
Discussion of hypotheses and evidence for various inflammation models.
Contextualization within SiHy lens designs, materials, and care solution components.

Main Results:

Multiple stimuli, including mechanical, allergic, and pathogen-driven factors, can induce inflammation in the anterior eye during SiHy lens wear.
SiHy lens materials and designs may influence susceptibility to these inflammatory responses.
Components within lens care solutions can also play a role in initiating or exacerbating ocular inflammation.

Conclusions:

The etiology of anterior eye inflammation in SiHy lens wearers is multifactorial.
Further research is needed to elucidate the precise interactions between lens characteristics, care solutions, and ocular tissues.
Optimizing SiHy lens materials, designs, and care solutions may help mitigate inflammatory complications.