[The interphase chromatin of lymphocyte nuclei in psoriasis patients]

Lymphocytic nuclei interphase chromatin was examined with the use of automated morphometry in psoriasis patients treated by different methods. Fifty optic and geometric parameters of lymphocytes were under study; the nuclear size and relative contrast, relative contrast of nongranular component, and chromatin pattern determined visually were found the most informative characteristics. The results evidence significant differences between the reference group of normal subjects and psoriasis patients. After treatment a tendency to normalization of the shifted parameters of interphase chromatin can be traced; PUVA therapy intensifies this process, and the parameters reach the reference values.