Related Experiment Video For Carcinogenesis
Updated: May 15, 2026

Granulocyte-dependent Autoantibody-induced Skin Blistering
Published on: October 12, 2012
Cutaneous squamous cell carcinoma developing from recessive dystrophic epidermolysis bullosa: a case report and an
Akira Tsukada1, Taku Fujimura, Sadanori Furudate
1Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai, Japan.
Abstract:
We describe a 49-year-old Japanese woman with cutaneous squamous cell carcinoma (SCC) developing from recessive dystrophic epidermolysis bullosa (RDEB). Interestingly, immunohistochemical staining revealed dense infiltration of CD163(+) M2 macrophages and numerous Foxp3(+) regulatory T cells (Tregs) around the tumor. Since the contribution of immunosuppressive factors (e.g. TGFβ) to the carcinogenesis of SCC from RDEB was recently reported, our present findings suggest one of the possible contributions of immunosuppressive cells, such as CD163(+) M2 macrophages and Tregs, to the carcinogenesis of SCC from RDEB.
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