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Published on: January 28, 2020
Inflammatory markers and lipid profile in patients of coronary artery disease
Toqueer Iqbal1, Nuzhat Raza, Zahid Irfan Marwat
1Department of Biochemistry, Ayub Medical College, Abbottabad, Pakistan. umairtoqueer@live.co.uk
Insights
This study found a weak positive correlation between inflammatory markers like C-reactive protein (CRP) and lipid levels, specifically LDL cholesterol, in coronary artery disease patients. Measuring both may aid early detection of cardiac event risk.
Area of Science:
- Cardiology
- Biochemistry
- Inflammation Research
Background:
- Coronary artery diseases (CAD) are linked to atherosclerosis.
- Understanding CAD pathology is crucial for cardiovascular health.
Purpose of the Study:
- To investigate the correlation between inflammatory markers and lipid profiles in CAD patients.
- To assess the potential of combined marker assessment for risk stratification.
Main Methods:
- Measured C-reactive protein (CRP) and fibrinogen levels in 100 CAD patients.
- Correlated inflammatory markers with lipid profile parameters: cholesterol, HDL, LDL, and triglycerides.
Main Results:
- A positive correlation was observed between CRP and LDL cholesterol and total serum cholesterol.
- No significant correlation was found between CRP and HDL or triglycerides.
- Fibrinogen showed no significant correlation with any lipid profile parameters.
Conclusions:
- Inflammatory markers and serum lipids exhibit a weak positive correlation in CAD.
- Simultaneous assessment of inflammatory markers and lipids may improve early detection of high-risk individuals for cardiac events.
Background:
Coronary artery diseases encompass a spectrum of disorders ranging from angina to fatal myocardial infarctions with the main underlying pathology being identified as atherosclerosis.
Methods:
The level of inflammatory markers, C-reactive protein and fibrinogen was determined in hundred patients with established coronary artery disease and correlated with lipid profile which included serum cholesterol, high density lipoprotein (HDL), low density lipoprotein and triglycerides.
Results:
The results showed a positive correlation between Inflammatory Marker CRP with LDL and serum cholesterol in patients with coronary artery disease. While no significant correlation of CRP was seen with high density lipoprotein (HDL) and triglyceride. Fibrinogen did not show any significant correlation with lipid profile parameters.
Conclusion:
Although the inflammatory markers were found to have weak positive correlation with the levels of serum lipids, determining both of these parameters together may help in the early detection and treatment of individuals who are at a high risk for cardiac events.
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